TAFFIC 25MG TABLET
Item requires a valid prescription
Manufactured By HETERO HEALTHCARE LTD GENX
Composition EMTRICITABINE 200MG TENOFOVIR ALAFENAMIDE 25MG BICTEGRAVIR 50MG
RS 3150.00
MRP RS 4500.00
(30% OFF)
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Description:
Taffic 25mg Tablet is a potent fixed-dose combination antiretroviral (ARV) tablet containing Bictegravir 50mg, Emtricitabine 200mg, and Tenofovir Alafenamide (TAF) 25mg, manufactured by Hetero Healthcare Ltd Genx. It is indicated for the treatment of HIV-1 infection in adults and adolescents (aged ≥12 years weighing ≥35 kg) as a complete single-tablet regimen (STR). Available from Shabbir Medical Hall at the best price in India, this genuine prescription tablet is available online with fast delivery nationwide.
BENEFITS: Taffic 25mg provides a highly effective, single-tablet regimen combining three complementary mechanisms: Bictegravir (an integrase strand transfer inhibitor/INSTI) blocks HIV integrase to prevent viral DNA integration into the host genome; Emtricitabine (FTC) and Tenofovir Alafenamide (TAF) are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) that block HIV reverse transcriptase, preventing viral replication. TAF delivers tenofovir directly into lymphoid cells at lower plasma levels, improving renal and bone safety compared to older tenofovir formulations. Clinical data demonstrate high rates of virologic suppression (HIV RNA <50 copies/mL) with a high barrier to resistance.
USAGE OVERVIEW: Taffic 25mg is taken orally, once daily, with or without food. Each tablet contains the full antiretroviral regimen — no additional ARV drugs are required for HIV-1-naive or virologically stable switch patients. Duration of therapy is lifelong unless otherwise directed by the treating HIV physician.
SAFETY OVERVIEW: Common side effects include diarrhoea, nausea, headache, fatigue, and abnormal dreams. Serious but rare adverse events include lactic acidosis, severe hepatomegaly with steatosis, and immune reconstitution inflammatory syndrome (IRIS). Regular monitoring of renal function, bone density, liver function, and HIV viral load is required. This medicine is NOT for use in children under 12 years or weighing less than 35 kg.
Uses / Indications:
- HIV-1 Infection (treatment-naive adults and adolescents): complete single-tablet regimen as initial therapy
- Virologically stable switch therapy: for HIV-1-infected adults currently on any antiretroviral regimen, to simplify treatment
- Patients with resistance to integrase inhibitors, NRTIs, or tenofovir (specialist use under HIV physician guidance)
ADDITIONAL USES:
- HIV-1 infection in adolescents aged ≥12 years and weighing ≥35 kg
- HIV post-exposure prophylaxis (off-label, in specific clinical contexts per HIV physician protocol)
Interactions / Warnings:
LACTIC ACIDOSIS WARNING
NRTIs (FTC, TAF) are associated with rare but serious risk of lactic acidosis and severe hepatomegaly with steatosis — DISCONTINUE if clinical or laboratory findings suggest this.
HEPATITIS B CO-INFECTION WARNING
Both FTC and TAF are active against hepatitis B virus (HBV). Severe acute exacerbation of hepatitis B can occur upon discontinuation — monitor liver function for several months after stopping. NEVER discontinue Taffic in HBV co-infected patients without specialist guidance.
RENAL IMPAIRMENT
TAF has improved renal safety vs TDF but requires monitoring. Taffic not recommended if eGFR <30 mL/min (limited data); use standard tenofovir disoproxil-based regimen under specialist guidance.
HEPATIC IMPAIRMENT
Mild-moderate hepatic impairment: no dose adjustment required. Severe hepatic impairment (Child-Pugh C): NOT recommended — insufficient data.
IMMUNE RECONSTITUTION
Monitor for IRIS — inflammatory flares of opportunistic infections in first weeks of ART.
DRIVING & MACHINERY
May cause dizziness and fatigue; assess personal response before driving.
Pregnancy interaction:
- Taffic 25mg (BIC/FTC/TAF) is used in pregnancy under specialist HIV physician supervision
- Emtricitabine and Tenofovir Alafenamide are established components of preferred HIV regimens in pregnancy
- Bictegravir data in pregnancy are more limited; use only when benefit outweighs risk as assessed by HIV specialist
- Antiretroviral therapy during pregnancy is essential to prevent mother-to-child HIV transmission (PMTCT)
- Register pregnancy with the Antiretroviral Pregnancy Registry (www.APRegistry.com)
BREASTFEEDING:
- HIV-infected mothers on ART are generally advised NOT to breastfeed to eliminate risk of HIV transmission to infant
- Drug components are excreted in human milk — consult HIV physician for infant feeding guidance
CONTRACEPTION WARNING:
- No specific contraceptive requirement; however, consistent contraception prevents unintended pregnancy and STI transmission
- Consult HIV physician regarding drug interactions with hormonal contraceptives
Expert advice:
1. ONCE-DAILY DOSING — NO FOOD RESTRICTION:
- Unlike older antiretroviral regimens, Taffic 25mg can be taken with or without food. However, taking it at the same time every day is critical to maintain consistent plasma drug levels and prevent virological failure. Set a daily phone alarm to establish a fixed dosing habit.
2. NEVER MISS A DOSE — RESISTANCE RISK IS REAL:
- Unlike many medications, missing HIV doses even occasionally can allow the virus to replicate and acquire drug resistance mutations. If you miss a dose by less than 18 hours, take it immediately. If more than 18 hours have passed, skip it and continue with the next scheduled dose. NEVER double up.
3. ANTACID AND SUPPLEMENT INTERACTION WARNING:
- Antacids, calcium supplements, iron tablets, multivitamins containing polyvalent cations (Mg, Al, Ca, Zn) must be separated from Taffic by at least 2 hours (before) or 6 hours (after). These minerals chelate bictegravir, significantly reducing its absorption.
4. HEPATITIS B CO-INFECTION — CRITICAL MONITORING:
- If you are co-infected with Hepatitis B, NEVER stop Taffic without your HIV physician's guidance. Discontinuing FTC and TAF (both anti-HBV active) can trigger a severe, potentially life-threatening hepatitis B flare. Liver function must be monitored for several months after any treatment change.
5. WATCH FOR LACTIC ACIDOSIS SIGNS:
- Unusual weakness, difficulty breathing, stomach pain, nausea, vomiting, or feeling cold in arms/legs may indicate lactic acidosis — a rare but serious NRTI complication. Report these symptoms to your HIV physician IMMEDIATELY and do NOT self-manage.
MONITORING ADVICE:
- HIV viral load (RNA copies/mL): Every 3 months until undetectable, then every 6 months
- CD4+ T-cell count: Every 3–6 months during first 2 years, then annually
- Renal function (serum creatinine, eGFR, urine dipstick): Before starting and every 6 months
- Liver Function Tests (LFTs): Baseline and periodically, more frequently in HBV co-infection
- Bone density (DXA scan): At baseline in at-risk patients (older age, low BMI, steroid use)
- Lipid profile: Annually (antiretrovirals can affect lipid metabolism)
- Blood glucose: Periodically, especially in diabetic patients
COMPLIANCE TIPS:
- Keep a medication diary with dose time and any side effects noticed
- Store tablets in original packaging away from moisture, heat, and sunlight
- Carry your HIV physician's prescription and a medication alert card at all times
- Do NOT crush, split, or chew tablets — swallow whole with water
- Disclose HIV status and full medication list to ALL treating doctors (dentist, GP, specialist) for safe prescribing
SAFETY TIPS:
- Do NOT stop Taffic without consulting your HIV physician — abrupt cessation risks viral rebound and resistance
- Maintain all scheduled HIV clinic appointments and laboratory tests
- Inform your physician immediately of any new medicines, herbal products, or supplements
- Use barrier contraception (condoms) consistently to prevent HIV transmission to partners
- During periods of illness, surgery, or stress, continue Taffic unless explicitly instructed otherwise by your HIV physician
Side Effects:
- Diarrhoea, nausea — typically mild and transient
- Headache, fatigue, dizziness
- Abnormal dreams, insomnia
- Elevated creatine kinase (muscle enzyme)
- Mild increases in liver transaminases (ALT, AST)
SERIOUS SIDE EFFECTS (contact your doctor immediately):
- Lactic Acidosis / Severe Hepatomegaly with Steatosis: rare but potentially life-threatening; symptoms include unexplained weakness, abdominal pain, difficulty breathing, nausea, vomiting — DISCONTINUE and seek urgent review
- Immune Reconstitution Inflammatory Syndrome (IRIS): inflammatory response to previously subclinical opportunistic infections (e.g., TB, CMV, PCP) in first weeks of therapy — monitor closely
- Renal Toxicity: assess renal function before and during therapy; discontinue if significant deterioration
- Bone Density Reduction: TAF has improved bone safety vs TDF but monitor bone density in at-risk patients
EMERGENCY SIGNS — SEEK IMMEDIATE MEDICAL HELP:
- Sudden weakness, abdominal pain, breathing difficulty (lactic acidosis symptoms)
- Jaundice (yellowing of skin/eyes) or severe abdominal pain
- Signs of severe allergic reaction: rash, facial swelling, difficulty breathing
How to use:
- Treatment-naive adults and adolescents (≥12 years, ≥35 kg): ONE tablet (BIC 50mg/FTC 200mg/TAF 25mg) ONCE DAILY
- Virologically stable switch: ONE tablet ONCE DAILY, replacing prior regimen
ROUTE OF ADMINISTRATION:
- Oral (film-coated tablet) — swallow whole with water
- Can be taken WITH or WITHOUT food (no food restriction unlike older ARVs)
- Take at the same time each day for consistent plasma levels
- Consistency is critical — irregular dosing increases risk of virological failure and resistance
MISSED DOSE:
- If missed within 18 hours of usual time, take immediately
- If more than 18 hours have passed, skip the missed dose and resume the next dose at the regular time
- NEVER double up doses
STORAGE:
- Store below 30°C in a dry place, away from moisture and sunlight
- Keep in original packaging with lid/foil intact
- Keep out of reach of children
- Do not use after the expiry date printed on the label
How it works:
1. BICTEGRAVIR (BIC) — Integrase Strand Transfer Inhibitor (INSTI):
- Selectively inhibits HIV-1 integrase, the enzyme responsible for inserting viral DNA into the host cell genome
- Without integration, HIV cannot establish persistent infection or replicate using the host's cellular machinery
- High genetic barrier to resistance — single mutations are unlikely to confer clinically significant resistance
2. EMTRICITABINE (FTC) — Nucleoside Reverse Transcriptase Inhibitor (NRTI):
- Incorporated into viral DNA as a cytidine analogue, causing chain termination during reverse transcription
- Prevents synthesis of HIV DNA from viral RNA
3. TENOFOVIR ALAFENAMIDE (TAF 25mg) — Nucleotide Reverse Transcriptase Inhibitor (NtRTI):
- A phosphonamidate prodrug of tenofovir; efficiently delivered into lymphoid cells (PBMCs)
- Activated intracellularly to tenofovir-diphosphate, which competitively inhibits HIV reverse transcriptase
- Lower plasma tenofovir levels vs. TDF — improved renal tubular and bone safety profile
COMBINED EFFECT:
- Dual NRTI backbone (FTC+TAF) + INSTI (BIC) = complete single-tablet HIV regimen
- Achieves and maintains HIV RNA suppression to undetectable levels (<50 copies/mL)
- Restores and preserves CD4+ T-cell count, reconstituting immune function
- High barrier to resistance — effective in both naive and switch patients
Faq for medicine:
Taffic 25mg (Bictegravir + Emtricitabine + Tenofovir Alafenamide) is a complete single-tablet antiretroviral regimen used to treat HIV-1 infection in adults and adolescents (≥12 years, ≥35 kg), taken once daily as directed by an HIV physician.
2. How does Taffic 25mg Bictegravir Emtricitabine Tenofovir Alafenamide Tablet work?
Bictegravir blocks HIV integrase to prevent viral DNA integration; Emtricitabine and Tenofovir Alafenamide inhibit HIV reverse transcriptase. Together, these three mechanisms suppress HIV-1 replication to undetectable levels, preserving CD4+ immune function.
3. What is the dose of Taffic 25mg Tablet for HIV-1?
Standard dose: ONE tablet (Bictegravir 50mg / Emtricitabine 200mg / Tenofovir Alafenamide 25mg) orally ONCE DAILY, with or without food. This is a complete HIV regimen — no additional antiretroviral agents required. Always follow your HIV physician's prescription.
4. What are the side effects of Taffic 25mg Tablet?
Most common: diarrhoea, nausea, headache, fatigue, abnormal dreams. Serious but rare: lactic acidosis, hepatitis B flare (on discontinuation in co-infected patients), immune reconstitution inflammatory syndrome (IRIS). Regular viral load and renal monitoring is mandatory.
5. Can I buy Taffic 25mg Tablet online at the best price in India?
Yes. Buy Taffic 25mg online from Shabbir Medical Hall at 30% OFF MRP (Rs 3,150 vs Rs 4,500 per pack of 30 tablets). Valid HIV physician prescription required. Fast delivery across Hyderabad, Bangalore, Mumbai, Delhi, and Chennai.
Medicine interaction:
- Antacids containing polyvalent cations (Mg²⁺, Al³⁺, Ca²⁺): chelate bictegravir — administer Taffic at least 2 hours before or 6 hours after antacids
- Rifampicin (strong CYP3A/P-gp inducer): significantly reduces BIC plasma levels — AVOID; use rifabutin as alternative
- Carbamazepine, oxcarbazepine, phenobarbital, phenytoin: strong inducers — AVOID co-administration
- St John's Wort: strong inducer — CONTRAINDICATED
- Metformin: TAF may increase metformin exposure via OCT2 inhibition — monitor renal function
- Other nephrotoxic drugs (NSAIDs, aminoglycosides, cyclosporine): increased renal toxicity risk — monitor renal function closely
- Atazanavir/cobicistat: increases TAF exposure significantly — not recommended
VACCINE INTERACTIONS:
- No specific vaccine interactions documented for BIC/FTC/TAF
- Patients on immunosuppressive therapy or with low CD4 counts should discuss live vaccine use with their HIV physician
SUPPLEMENT INTERACTIONS:
- Multivitamins and mineral supplements containing iron, calcium, magnesium, zinc: separate Taffic dose by at least 2 hours
- Always inform your doctor of all vitamins, herbal products, and supplements
