RIVAJON 20MG TABLET
Manufactured By JOHNLEE PHARMACEUTICALS PVT LTD
Composition RIVAROXABAN 20MG
RS 354.38
MRP RS 506.25
(30% OFF)
Includes all taxes
Package SIZE
( 14`S )
100% Authentic
Products
Free
Shipping*
Products
Return Policy
Description:
Rivajon 20mg Tablet
Rivajon 20mg Tablet is a potent oral anticoagulant (blood thinner) containing Rivaroxaban 20mg, manufactured by Johnlee Pharmaceuticals Pvt Ltd. It belongs to the class of Direct Oral Anticoagulants (DOACs) and acts as a selective Factor Xa inhibitor. Available from Shabbir Medical Hall at the best price in India with 30% OFF MRP, this genuine prescription medicine is available online with fast delivery nationwide.
BENEFITS: Rivajon 20mg provides highly effective prevention and treatment of blood clot-related conditions without the dietary restrictions and frequent blood monitoring associated with older anticoagulants like warfarin. By selectively inhibiting Factor Xa — the pivotal enzyme in the coagulation cascade — Rivaroxaban prevents the conversion of prothrombin to thrombin, thereby blocking new clot formation and stopping existing clots from growing. Key clinical benefits include once-daily dosing (with evening meal for 20mg), predictable pharmacokinetics, no routine INR monitoring required, and a broad range of approved indications spanning prevention of stroke in non-valvular atrial fibrillation (NVAF), treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT/PE.
USAGE OVERVIEW: Rivajon 20mg Tablet is taken orally, ONCE DAILY with the evening meal for most indications. Treatment duration and dosing frequency vary by indication: 20mg once daily for stroke prevention in NVAF and long-term VTE treatment; initial 15mg twice daily for the first 3 weeks of acute DVT/PE treatment (under cardiologist/physician guidance). Rivaroxaban 10mg is used for VTE prophylaxis post-orthopaedic surgery (knee/hip replacement).
SAFETY OVERVIEW: The most important risk is bleeding — patients should watch for unusual bruising, prolonged bleeding from cuts, blood in urine or stools, or coughing/vomiting blood. No routine INR monitoring is required, but renal and hepatic function should be assessed periodically. This medicine should NEVER be stopped abruptly without physician guidance, as doing so significantly increases the risk of stroke in NVAF patients. Prescription required — always use under cardiologist/physician supervision.
Uses / Indications:
- Stroke Prevention in Non-Valvular Atrial Fibrillation (NVAF): prevents stroke and systemic embolism in adults with NVAF and at least one risk factor for stroke
- Treatment of Deep Vein Thrombosis (DVT): treatment of acute DVT following initial 15mg BD for 3 weeks phase
- Treatment of Pulmonary Embolism (PE): treatment of acute PE following the initial 15mg BD phase
- Prevention of Recurrent DVT and PE (long-term secondary prevention): 20mg once daily after completing at least 6 months of DVT/PE treatment
USES OF RIVAROXABAN 10MG (REFERENCE):
- Prophylaxis of VTE following elective knee replacement surgery: 10mg once daily for 2 weeks
- Prophylaxis of VTE following elective hip replacement surgery: 10mg once daily for 5 weeks
- Extended VTE prophylaxis in medically ill patients (Betrixaban-comparable indication, under cardiologist guidance)
ADDITIONAL USES (SPECIALIST GUIDANCE):
- Prevention of atherothrombotic events in patients with acute coronary syndrome (ACS): 2.5mg BD (lower dose, different product)
- Secondary prevention in patients with stable CAD or PAD (2.5mg BD with aspirin)
Note: 2.5mg and 10mg doses are separate products; Rivajon 20mg is specifically for NVAF stroke prevention, DVT/PE treatment, and recurrent VTE prevention
Interactions / Warnings:
BLEEDING RISK WARNING (PRIMARY SAFETY CONCERN): Rivaroxaban INCREASES THE RISK OF BLEEDING — any invasive procedure, surgery, trauma, or fall significantly raises the risk of serious haemorrhage. Inform ALL healthcare providers (surgeon, dentist, emergency doctor) that you are taking rivaroxaban BEFORE any procedure. Specific antidote: Andexanet alfa (Ondexxya) — approved reversal agent for rivaroxaban-associated life-threatening bleeding (specialist hospital use only).
ABRUPT DISCONTINUATION WARNING: In patients with NVAF: NEVER stop rivaroxaban abruptly without physician instruction — this sharply increases stroke risk. If transitioning to another anticoagulant: follow physician-guided bridging protocol.
RENAL IMPAIRMENT: Moderate renal impairment (CrCl 30–50 mL/min): use with caution; increased drug exposure. Severe renal impairment (CrCl 15–29 mL/min): use with extreme caution; for NVAF reduce to 15mg once daily in some guidelines. CrCl <15 mL/min: NOT recommended. Monitor renal function at least annually during long-term therapy.
HEPATIC IMPAIRMENT: Mild hepatic impairment (Child-Pugh A): use with caution. Moderate to severe hepatic impairment (Child-Pugh B or C): CONTRAINDICATED. Hepatic disease associated with coagulopathy: CONTRAINDICATED.
ELDERLY PATIENTS (>75 years): Higher bleeding risk due to age-related renal function decline and increased fall risk. Regular renal function monitoring and falls assessment recommended.
SPINAL/EPIDURAL ANAESTHESIA WARNING: Epidural catheters should NOT be removed within 18 hours of last rivaroxaban dose. Next rivaroxaban dose should not be given for at least 6 hours after catheter removal. Risk of epidural haematoma causing permanent paralysis — inform anaesthetist in advance.
Pregnancy interaction:
- Rivaroxaban is CONTRAINDICATED in pregnancy — animal studies have shown reproductive toxicity including foetal haemorrhage
- Potential for serious haemorrhagic complications in the foetus/neonate given placental transfer
- No adequate and well-controlled studies in pregnant women
- If anticoagulation is required during pregnancy: low molecular weight heparin (LMWH) is the preferred agent under haematologist/obstetrician guidance
- WOMEN OF CHILDBEARING POTENTIAL: use effective contraception during rivaroxaban therapy
- If pregnancy is detected during treatment: STOP rivaroxaban immediately and consult physician urgently
BREASTFEEDING:
- Rivaroxaban is excreted in human milk — CONTRAINDICATED during breastfeeding
- A decision must be made whether to disco
Expert advice:
1. ALWAYS TAKE RIVAJON 20MG WITH YOUR EVENING MEAL — NEVER ON AN EMPTY STOMACH:
- This is critically important. Rivaroxaban 20mg has approximately 66% bioavailability when taken without food, rising to near-complete absorption (~100%) when taken with food. Taking Rivajon 20mg on an empty stomach significantly reduces its anticoagulant effect, increasing the risk of stroke or clot. The evening meal timing also ensures consistent peak drug levels overnight when clotting risk is highest in AF patients.
2. NEVER STOP RIVAJON 20MG WITHOUT YOUR CARDIOLOGIST'S INSTRUCTION:
- Abruptly stopping rivaroxaban in patients with atrial fibrillation dramatically increases the risk of ischaemic stroke within days. If you experience side effects or run out of medicine, contact your cardiologist IMMEDIATELY. Do not substitute with another blood thinner without explicit physician guidance — dosing equivalence between anticoagulants is complex and dangerous to self-manage.
3. TELL EVERY HEALTHCARE PROVIDER YOU TAKE RIVAJON 20MG:
- Before any dental procedure, surgery, colonoscopy, or even minor procedure, your doctor or dentist must know you are on rivaroxaban. Stopping it too early risks clotting; not stopping it risks excessive surgical bleeding. Your cardiologist will provide guidance on when to pause and resume — typically stopping 24–48 hours before elective procedures.
4. RECOGNISE BLEEDING WARNING SIGNS IMMEDIATELY:
- Any unusual or prolonged bleeding demands same-day medical attention. Red flags: black or tarry stools (GI bleed), pink/red/dark-brown urine (urinary tract bleed), unexplained bruising spreading rapidly, coughing or vomiting blood, sudden severe headache (intracranial bleed), or joint swelling and pain (intra-articular bleed). These are emergencies — go to your nearest emergency department, do NOT wait for a routine appointment.
5. AVOID NSAIDs, ASPIRIN, AND HERBAL BLOOD THINNERS UNLESS EXPLICITLY APPROVED BY YOUR CARDIOLOGIST:
- Common over-the-counter painkillers like ibuprofen, diclofenac, and aspirin significantly increase bleeding risk when combined with rivaroxaban. St John's Wort (herbal antidepressant) drastically reduces rivaroxaban levels and is absolutely contraindicated. Fish oil, vitamin E, garlic, and ginkgo supplements can also add mild antiplatelet effects — always disclose all supplements.
MONITORING ADVICE:
- Renal function (serum creatinine, eGFR): Baseline, then annually (or more frequently if age >75 or renal disease)
- Liver Function Tests (LFTs): Baseline; periodically during long-term therapy
- Full Blood Count (FBC): Periodically — check for anaemia from occult bleeding
- Blood pressure: Regular monitoring (hypertension increases stroke and bleeding risk)
- INR: NOT required for rivaroxaban monitoring (a key advantage over warfarin)
- Weight: Monitor if significant weight change occurs — may affect dosing
- Renal function: Review before and after any major illness, dehydration, or hospitalisation
COMPLIANCE TIPS:
- Take EVERY evening with your main meal — link it to a daily mealtime routine
- Never crush tablets unless necessary (if swallowing difficulty, follow crush-and-mix protocol with food)
- Store in original packaging below 30°C — away from moisture and sunlight
- Do NOT share this medicine or allow others to use it — dosing is highly individual
SAFETY TIPS:
- Avoid contact sports, high fall-risk activities, or situations with significant injury risk during therapy
- Use soft-bristle toothbrush and electric shaver to reduce minor bleeding
- Inform emergency services/paramedics you are on rivaroxaban if involved in an accident
- If you miss a dose of 20mg once daily — take it the SAME DAY as soon as remembered; never double up the next day
- Alcohol: Moderate consumption may be acceptable, but excessive alcohol increases bleeding risk and liver stress — limit intake
Side Effects:
- Bleeding events: nosebleeds, bleeding gums, bruising more easily than usual
- Gastrointestinal: nausea, vomiting, constipation, diarrhoea, abdominal pain/discomfort
- Elevated liver enzymes (ALT, AST, GGT) — usually asymptomatic and transient
- Dizziness, headache
- Anaemia (due to occult bleeding)
- Oedema (swelling of limbs)
SERIOUS SIDE EFFECTS — SEEK IMMEDIATE MEDICAL ATTENTION:
- Major Bleeding Events (uncommon but life-threatening):
- Intracranial haemorrhage (sudden severe headache, weakness, vision changes, loss of consciousness)
- Gastrointestinal bleeding (red or black tarry stools, vomiting blood or coffee-ground material)
- Haemoptysis (coughing blood)
- Haematuria (blood in urine — pink or red urine)
- Intraocular bleeding (sudden vision loss)
- Retroperitoneal, intramuscular, or intra-articular bleeding
- Hepatotoxicity (rare): jaundice, dark urine, severe right upper abdominal pain
- Severe hypersensitivity / anaphylaxis: rash, facial swelling, difficulty breathing — SEEK EMERGENCY HELP
- Adrenal insufficiency (rare): fatigue, weakness, abdominal pain (if adrenal gland bleeding)
EMERGENCY SIGNS — CALL EMERGENCY SERVICES IMMEDIATELY:
- Any sudden, severe, or unusual bleeding that does not stop
- Sudden severe headache (possible intracranial bleed)
- Blood in urine, stool, or vomit
- Signs of severe allergic reaction
How to use:
RIVAJON 20MG INDICATIONS:
- Stroke prevention in NVAF: 20mg ONCE DAILY with the EVENING MEAL — lifelong unless directed otherwise
- DVT/PE treatment (after initial phase): 20mg ONCE DAILY with food — for at least 3 months; duration per physician
- Recurrent DVT/PE prevention (long-term): 20mg ONCE DAILY with food
INITIAL DVT/PE TREATMENT PHASE (first 3 weeks — DIFFERENT DOSE):
- 15mg TWICE DAILY with food for Days 1–21 (Note: requires Rivaroxaban 15mg product — not Rivajon 20mg)
- Switch to 20mg once daily from Day 22 onwards
ROUTE OF ADMINISTRATION:
- Oral (film-coated tablet) — swallow whole with water
- MUST be taken with food (evening meal) for the 20mg dose — food significantly increases absorption
- If patient cannot swallow tablet: crush and mix with water or apple puree, take immediately; follow immediately with food
TIMING:
- Take at the SAME TIME every evening with the evening meal
- Consistency is critical — irregular dosing increases stroke and VTE risk
MISSED DOSE:
- 20mg once daily: take missed dose on the SAME DAY as soon as remembered; do not take two doses in one day
- 15mg twice daily (initial DVT/PE phase): take immediately if remembered on the same day, even if it means taking two doses in one day to maintain the 15mg twice daily regimen
STORAGE:
- Store below 30°C in original packaging, away from moisture and sunlight
- Keep out of reach of children
- Do not use after expiry date printed on the label
How it works:
COAGULATION CASCADE — WHERE RIVAROXABAN ACTS:
- Normal clotting requires a cascade of enzymatic reactions ultimately producing thrombin, which converts fibrinogen to fibrin, forming the clot
- Factor Xa sits at the convergence of the extrinsic and intrinsic pathways — blocking it simultaneously interrupts both pathways
MECHANISM OF ACTION:
1. Direct Factor Xa Inhibition:
- Rivaroxaban directly binds to the active site of Factor Xa with high selectivity (Ki ~0.4 nM)
- Inhibits both free Factor Xa and prothrombinase complex-bound Factor Xa
- Does NOT require antithrombin III as a cofactor (unlike heparin) — works independently
2. Downstream Effects:
- Inhibits thrombin generation — reduces conversion of prothrombin to thrombin
- Prevents fibrin clot formation — stops new clots forming and restricts existing clot growth
- Does NOT directly inhibit thrombin (Factor IIa) — spares platelet aggregation to a greater degree than direct thrombin inhibitors
3. Pharmacokinetics:
- Oral bioavailability: ~66% (fasted) to ~100% (20mg with food) — MUST be taken with food for the 20mg dose
- Onset of action: 2–4 hours post-dose
- Half-life: 5–9 hours (young adults); 11–13 hours (elderly)
- Dual elimination: 2/3 metabolised (CYP3A4/CYP2J2), 1/3 excreted unchanged renally
- No routine INR or anti-Xa monitoring required in clinical practice
Faq for medicine:
Rivajon 20mg (Rivaroxaban 20mg) is used to prevent stroke and blood clots in adults with non-valvular atrial fibrillation (AF), and to treat and prevent recurrence of deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a once-daily prescription anticoagulant.
2. How does Rivajon 20mg Rivaroxaban Tablet work?
Rivaroxaban directly inhibits Factor Xa, the pivotal enzyme where the extrinsic and intrinsic coagulation pathways converge. This prevents thrombin generation and fibrin clot formation, reducing the risk of stroke, DVT, and PE without requiring routine INR blood monitoring like warfarin.
3. What is the correct dose and timing for Rivajon 20mg Tablet?
Standard dose: ONE tablet (Rivaroxaban 20mg) ONCE DAILY with the EVENING MEAL. Taking it with food is mandatory for full absorption and anticoagulant efficacy. Never stop abruptly — always follow your cardiologist's or physician's instructions for dose and duration.
4. What are the side effects of Rivajon 20mg Tablet?
Most common: nausea, bruising, nosebleeds, elevated liver enzymes. Serious but rare: major bleeding (GI bleed, intracranial haemorrhage — blood in stool/urine, sudden severe headache). Seek emergency help immediately for any unusual or uncontrolled bleeding. Never self-manage.
5. Can I buy Rivajon 20mg Tablet online at the best price in India?
Yes. Buy Rivajon 20mg online from Shabbir Medical Hall at 30% OFF MRP (Rs 354.38 vs Rs 506.25 per strip of 14 tablets). Valid cardiologist or physician prescription required. Fast delivery across Hyderabad, Bangalore, Mumbai, Delhi, and Chennai.
Medicine interaction:
- Strong CYP3A4 + P-gp inhibitors — Azole antifungals: ketoconazole, itraconazole, voriconazole, posaconazole — significantly increase rivaroxaban exposure → increased bleeding risk — AVOID or use with extreme caution
- HIV protease inhibitors with ritonavir/cobicistat — CONTRAINDICATED
- Clarithromycin, erythromycin — moderate increase; use cautiously
- Strong CYP3A4 + P-gp inducers — Rifampicin — dramatically reduces rivaroxaban plasma levels → loss of anticoagulant effect → thrombotic risk — AVOID
- Carbamazepine, phenytoin, phenobarbital, St John's Wort — CONTRAINDICATED
- Other anticoagulants/antiplatelets: Warfarin, heparin, aspirin, clopidogrel, NSAIDs, SSRIs, SNRIs — all increase bleeding risk; use only when clinically essential with close monitoring
- Dronedarone: significantly increases rivaroxaban exposure — AVOID
VACCINE INTERACTIONS:
- No specific vaccine interactions documented for Rivaroxaban; inform your cardiologist of any upcoming vaccinations or procedures during treatment
SUPPLEMENT INTERACTIONS:
- St John's Wort: ABSOLUTELY CONTRAINDICATED — reduces rivaroxaban levels significantly
- Fish oil (Omega-3), Vitamin E supplements: mild antiplatelet effect — additive bleeding ri
Available Substitutes
