Metagem is a drug for angina pectoris sold under the brand name Metagem. Metagem is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France). Metagem is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase Activity, which results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation. High fatty acid oxidation rates are detrimental during ischemia due to an inhibition of glucose oxidation leading to uncoupling of glycolysis and an increase in proton production, which has the potential to accelerate sodium and calcium overload in the heart, which leads to an exacerbation of ischemic injury and decreased cardiac efficiency during

Some diabetic patients taking MetGem 500 Tablet 10's may develop a serious condition called lactic acidosis. In lactic acidosis, there is too much lactic acid accumulated in the blood. So, your liver and kidney proper functioning is required for the elimination of excess lactic acid from the blood. You should not take metformin if you have kidney disease, as measured by a blood test. MetGem 500 Tablet 10's may lower vitamin B-12 levels, so try to have blood test annual blood and vitamin. MetGem 500 Tablet 10's, when used with insulin, may extremely lower the blood sugar level. So, the doctor may lower the dose of insulin.