Each tablet contains Glimepiride Isryl M 1 mg and Metformin Isryl M HCl in sustained release form 500 mg It also contains the following excipients Hypromellose sodium carboxymethyl cellulose methacrylic acid copolymer dispersion macrogol povidone magnesium stearate purified water sodium starch glycolate lactose titanium dioxide microcrystalline cellulose magnesium stearate and pregelatinized starch Colors Yellow ferric oxide and titanium dioxide

Some diabetic patient taking Isryl M1 Tablet 15 s may develop a serious condition called lactic acidosis In lactic acidosis there is too much of lactic acid accumulated in the blood So your liver and kidney proper functioning is required for the elimination of excess lactic acid from the blood You should not take metformin if you have kidney disease as measured by a blood test Isryl M1 Tablet 15 s may lower vitamin B12 levels so try to have blood test annual blood and vitamin Metformin when used with insulin may extremely lower the blood sugar level So the doctor may lower the dose of insulin