Description:
Flagyl is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).
Flagyl belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, Flagyl will not work for colds, flu, or other virus infections.
Flagyl is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Flagyl is used in certain patients with the following medical conditions:
Clostridium difficile diarrhea or colitis (antibiotic-associated colitis).
Crohn's disease (inflammatory bowel disease).
Gastritis or stomach ulcers due to Helicobacter pylori.
Giardiasis (parasite infection in the intestines).
Uses / Indications:
Flagyl 400 Tablet is a prescription medicine that is used to treat a sexually transmitted infection (called symptomatic trichomoniasis). This medicine works by interacting with DNA that interferes with the DNA synthesis that leads to the end of bacteria. Flagyl 400 Tablet is also used to treat a genitourinary infection (called asymptomatic trichomoniasis), to treat asymptomatic sexual partners, to treat a parasitic infection of the colon (amebiasis) and a parasitic infection of the small intestine (giardiasis), to treat certain anaerobic bacterial infections that include intra-abdominal infections, skin and skin structure infections, female reproductive organ (gynecologic) infections, blood poisoning (bacterial septicemia), lower respiratory tract infection, serious heart infection (endocarditis), central nervous system infections, and bone and joint infections, to prevent the infections that may occur before, during or after the operation of the intestine (elective colorectal surgery), to treat acute dental infections e.g. painful infection of the gums (acute ulcerative gingivitis or acute pericoronitis) and pus inside the teeth (acute apical infections), and to treat anaerobically-infected leg ulcers and pressure sores.
Interactions / Warnings:
Flagyl 400 Tablet 15's should not be used during pregnancy, especially during the first trimester. So, let your doctor know if you are pregnant or planning to get pregnant. You should not breastfeed while taking Flagyl 400 Tablet 15's as it passes into the breastmilk, and can affect the baby. Do not drive or operate heavy machinery after taking Flagyl 400 Tablet 15's as it may cause dizziness, drowsiness and make you less alert. Do not take Flagyl 400 Tablet 15's if you are allergic to Flagyl 400 Tablet 15's or other antibiotics, blood thinners (coumarins, warfarin), anti-epileptic drugs (phenobarbital, phenytoin, primidone), anti-cancer drugs (busulfan, fluorouracil, mycophenolate). You should immediately report to the doctor in case you have symptoms of dehydration like dehydration dry mouth, excessive thirst, wrinkled skin, little or no urination, dizziness and lightheadedness. In some cases, prolonged intake of Flagyl 400 Tablet 15's has been associated with leukopenia (low count of white blood cells). Use of Flagyl 400 Tablet 15's is contraindicated in the patient suffering from central nervous system (CNS) diseases like seizures (fits). Intake of probiotics, prebiotics and plenty of fluids is recommended if you are suffering from dysentery and diarrhoea.
Side Effects:
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Itching in the vagina
pain during sexual intercourse
thick, white vaginal discharge with no odor or with a mild odor
Less common
Abdominal or stomach cramping or pain
burning on urination or need to urinate more often
burning or irritation of penis of sexual partner
itching, stinging, or redness of the genital area
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Diarrhea
dizziness or lightheadedness
dryness of the mouth
feeling of a furry tongue
headache
loss of appetite
metallic taste or other change in taste sensation
Nausea
vomiting
Flagyl may cause your urine to become dark. This is harmless and will go away when you stop using Flagyl.
After you stop using Flagyl, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:
Any vaginal or genital irritation or itching
pain during sexual intercourse
thick, white vaginal discharge not present before treatment, with no odor or with a mild odor
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Medicine interaction:
When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Flagyl 400 Tablet interacts with warfarin and other oral anticoagulants, which are used to prevent blood clots. The patients who use Flagyl 400 in combination with anticoagulants such as warfarin may experience an increased anticoagulant effect of warfarin and other oral anticoagulants, which may further prolong the blood clotting time. In such patients, the time that blood takes to clot (prothrombin time and international normalized ratio) should be carefully monitored.
There may be an interaction of Flagyl 400 with alcoholic beverages, which is an alcoholic drink containing ethanol, known as alcohol. The patients undergoing treatment with Flagyl 400 may experience cramps in stomach, Nausea, vomiting, headache, and flushing if they consume alcohol or substances containing propylene glycol during or after treatment. Patients who are on treatment with Flagyl 400 should stop consumption of alcohol or products that contain propylene glycol during and after three days of therapy with Flagyl 400.
Flagyl 400 Tablet may interact with disulfiram, which is used for the treatment of alcoholism. The patients who use Flagyl 400 in combination with disulfiram may develop mental problems (psychotic reactions). The patients who have taken disulfiram within the last two weeks should not take Flagyl 400.
Your doctor's guidelines may need to be followed while taking this medicine along with Busulfan, which is used in the treatment of certain types of cancers. The patients who use Flagyl 400 in combination with busulfan may experience an increase in the levels of busulfan in the blood, which may result in an increased risk of harmful effects of busulfan due to its accumulation. Patients who are on treatment with Flagyl 400 should not be given busulfan if the benefit by busulfan is less than the risk. If there is no other treatment available, the levels of busulfan in the blood should be monitored routinely and its dose should be adjusted properly.
Special instructions need to be followed while taking this medicine along with lithium, which is used to treat a major depressive disorder. The patients who are on high dose levels of lithium and who undergo short-term treatment with Flagyl 400 have been associated with increased levels of lithium in the blood. In some cases, lithium poisoning may occur due to high levels of lithium. The levels of lithium and creatinine in the blood should be monitored after certain days of beginning treatment with Flagyl 400 to recognize any increase that may lead to clinical symptoms of damage due to lithium accumulation.
Your doctor's guidelines may need to be followed while taking this medicine along with 5 fluorouracil, which is used in the treatment of cancer. When Flagyl 400 is given along with 5 fluorouracil, the clearance of 5 fluorouracil is decreased and the accumulation of 5 fluorouracil can result in harmful effects.
Special instructions need to be followed while taking this medicine along with ciclosporin, which is used as an immunosuppressant. The patients who use Flagyl 400 in combination with ciclosporin may experience an increase in ciclosporin levels in the blood. Patients who are on treatment with both Flagyl 400 and ciclosporin should closely monitor the levels of ciclosporin and creatinine in the blood.
Flagyl 400 Tablet interacts with drug or laboratory tests. The patients who use Flagyl 400 may interfere with certain types of tests of blood chemistry values such as aspartate aminotransferase, lactate dehydrogenase, alanine aminotransferase, triglycerides, and glucose hexokinase and the values of zero have been observed.
There may be an interaction of Flagyl 400 with drugs that induce CYP450 enzymes such as phenytoin or phenobarbital, which is used for the prevention of tonic-clonic seizures. The patients who use Flagyl 400 in combination with the drugs that induce microsomal liver enzymes such as phenytoin or phenobarbital may enhance the elimination of Flagyl 400. It results in reduced levels of Flagyl 400 in the blood and disrupted clearance of phenytoin has also been reported.
Flagyl 400 Tablet may interact with drugs that prevent CYP450 enzymes such as cimetidine, which is used to treat certain types of ulcers. The patients who use Flagyl 400 in combination with the drugs that prevent CYP450 enzymes such as cimetidine may increase the level and decrease the clearance of Flagyl 400 from the blood.
This page does not contain all the possible interactions of Flagyl 400 Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.
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