Oleanz Plus Tablet is used for the short-term treatment and maintenance of a severe mental illness that affects a person's ability to think, feel, and behave (schizophrenia). It is a prescription medicine. This medicine works by altering the Activity of certain natural substances in the brain. Oleanz Plus is also used for the short-term treatment and maintenance of mood disorder (mania associated with bipolar-I disorder). It is also used to treat excessive brain Activity associated with mental illness and mood swings (agitation related to schizophrenia and bipolar-I disorder associated mania). Oleanz Plus Tablet may also be taken in combination with other medicines to treat certain conditions as recommended by the doctor. Oleanz Plus Tablet is used together with Lithium or Valproate for the short-term treatment of mood swings and mixed episodes of major depression related to bipolar-I disorder in adults. Oleanz Plus is also used with Fluoxetine to treat depressive episodes and the condition in which patients are unable to respond to antidepressant therapy associated with Bipolar I Disorder in adult patients.