Eliquis 2.5mg Tablet
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Manufactured By Bms India Pvt Ltd
Composition Apixaban 2 5mg
RS 346.64
MRP RS 407.81
(15% OFF)
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( 10 tablets in 1 strip )
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Description:
Eliquis 2.5mg Tablet (Apixaban 2.5mg) is an oral anticoagulant (blood thinner) belonging to the class of direct Factor Xa inhibitors, manufactured by BMS India Pvt Ltd (Bristol-Myers Squibb / Pfizer) and used to prevent and treat life-threatening blood clots in adults. It is prescribed to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation (irregular heartbeat), and to prevent and treat deep vein thrombosis (DVT) and pulmonary embolism (PE). It is also used after elective hip or knee replacement surgery to reduce clot formation risk. Available from Shabbir Medical Hall at the best price in India, this genuine prescription medicine is easy to order online with fast home delivery.
BENEFITS: Eliquis 2.5mg works by selectively blocking Factor Xa — a pivotal enzyme in the blood coagulation cascade — preventing the conversion of prothrombin to thrombin and, ultimately, stopping clot formation. Unlike older anticoagulants such as warfarin, Eliquis does not require routine blood monitoring (PT-INR tests), offers predictable pharmacokinetics, and has fewer food interactions, making it a preferred choice in modern cardiovascular care.
USAGE OVERVIEW: Take Eliquis 2.5mg exactly as prescribed by your cardiologist or physician. For atrial fibrillation, the typical dose is 2.5mg or 5mg twice daily. For post-surgical DVT prevention, 2.5mg twice daily is standard. Swallow tablets whole with or without food at the same time each day. Never stop treatment without consulting your doctor as this increases the risk of stroke or clot recurrence.
SAFETY OVERVIEW: The most common side effect is an increased tendency to bleed (bruising, nosebleeds). Serious effects such as major bleeding episodes, blood in stools or urine, or sudden severe headache require immediate medical attention. Inform your doctor about all current medications, liver or kidney conditions, and pregnancy status before starting therapy.
Uses / Indications:
• Non-valvular Atrial Fibrillation (AF) — reduction of risk of stroke and systemic embolism
• Deep Vein Thrombosis (DVT) — treatment and prevention of recurrence
• Pulmonary Embolism (PE) — treatment and prevention of recurrence
• Prevention of DVT/PE after elective hip or knee replacement surgery
ADDITIONAL USES:
• Secondary prevention of cardiovascular events in selected high-risk patients
• Management of venous thromboembolism (VTE) in cancer patients (off-label in select protocols)
• Dose reduction regimen (2.5mg twice daily) in elderly/low-body-weight AF patients
Interactions / Warnings:
LIVER DISEASE: Eliquis 2.5mg is NOT recommended in patients with severe hepatic impairment or liver disease associated with coagulopathy. Patients with mild to moderate liver disease should use with caution — consult doctor.
KIDNEY DISEASE: Use with caution in patients with moderate to severe renal impairment (CrCl <25 ml/min or eGFR <15). Not recommended in patients on dialysis — consult your nephrologist.
HEART CONDITIONS: Eliquis is primarily used in AF patients — it replaces warfarin in many cases. Patients with prosthetic (mechanical) heart valves should NOT use Eliquis; warfarin is preferred.
ALLERGY WARNING: Do not use Eliquis 2.5mg if you are allergic to Apixaban or any excipients in the formulation.
ELDERLY USE (≥75 years): Use with increased caution — dose reduction criteria apply. Elderly patients are at higher risk of bleeding. The 2.5mg dose is specifically calibrated for eligible elderly AF patients meeting specific criteria (age ≥80, weight ≤60kg, creatinine ≥1.5mg/dL — any two of three triggers dose reduction).
DRIVING & MACHINERY: Eliquis may cause dizziness or fainting (from hypotension or anaemia-related weakness). Patients should assess their response before driving.
Pregnancy interaction:
• The effects of Apixaban on pregnancy and the unborn baby are not fully established.
• Eliquis 2.5mg is generally NOT recommended during pregnancy due to potential risk of fetal harm (possible haemorrhage, teratogenicity based on animal studies).
• Women of childbearing potential should use effective contraception during treatment.
• Inform your doctor immediately if pregnancy is suspected or confirmed during treatment.
BREASTFEEDING:
• It is not known if Apixaban passes into human breast milk.
• Breastfeeding is NOT recommended while taking Eliquis 2.5mg as a precautionary measure.
• Discuss alternative feeding options with your doctor.
CONTRACEPTION WARNING / DOCTOR CONSULTATION WARNING:
• Never start, stop, or change Eliquis dosing without consulting your cardiologist or physician. Stopping abruptly significantly increases stroke risk in AF patients.
Expert advice:
1. NEVER STOP ABRUPTLY
• Stopping Eliquis suddenly without medical guidance significantly increases your risk of stroke or clot recurrence, especially if you have atrial fibrillation. Always consult your cardiologist before making any changes.
2. CONSISTENT TWICE-DAILY TIMING
• Take your doses approximately 12 hours apart (e.g., 8 AM and 8 PM) every day for stable plasma drug levels and maximum efficacy.
3. NO ROUTINE BLOOD MONITORING NEEDED
• Unlike warfarin, Eliquis does not require regular INR/PT blood tests. However, periodic kidney and liver function checks are still recommended by your doctor.
4. BLEEDING PRECAUTIONS
• Inform all healthcare providers (dentists, surgeons, emergency doctors) that you are on Apixaban before any procedure. Carry a medication alert card or use a medical ID bracelet.
5. REPORT ALL MEDICINES
• Always inform your cardiologist and pharmacist about every medicine, supplement, or herbal product you are taking before starting Eliquis.
MONITORING ADVICE:
• Kidney function (serum creatinine / eGFR): At baseline and at least annually — dose adjustment thresholds depend on renal function.
• Liver function tests (LFTs): Baseline and periodically; Apixaban is contraindicated in significant hepatic impairment.
• Full Blood Count (FBC/CBC): If symptoms of anaemia appear (fatigue, pallor, shortness of breath).
• Blood pressure monitoring: Hypertension increases stroke risk even on anticoagulants.
COMPLIANCE TIPS:
• Store tablets in original child-proof packaging in a cool, dry location.
• Use a pill organiser or phone alarm to remember twice-daily doses.
• Never share your prescription medicine with others.
• Keep all scheduled cardiology follow-up appointments.
• Do not take OTC pain relievers (ibuprofen, aspirin) without consulting your doctor — they significantly increase bleeding risk with Apixaban.
SAFETY TIPS:
• Use a soft-bristle toothbrush and electric razor to minimise bleeding from minor cuts.
• Avoid contact sports and activities with high injury risk.
• If you cut yourself and bleeding does not stop within 10 minutes of direct pressure, seek medical attention.
• Dispose of unused tablets through a pharmacy take-back programme — never flush or bin them.
Side Effects:
• Increased tendency to bleed (bruising, nosebleeds, bleeding gums)
• Anaemia (low red blood cell count — fatigue, pallor, weakness)
• Haematoma (collection of blood under the skin)
• Nausea and mild dizziness
• Low blood pressure (hypotension)
• Skin rash
SERIOUS SIDE EFFECTS (contact your doctor immediately):
• Major bleeding episodes — blood in vomit, stools (black/tarry stools), or urine (pink/red/brown urine)
• Coughing up blood
• Intracranial/spinal haemorrhage — sudden severe headache, vision changes, confusion, weakness
• Retroperitoneal or intra-abdominal bleeding — persistent abdominal pain
• Severe bruising or unusual swelling
EMERGENCY WARNING SIGNS — SEEK IMMEDIATE MEDICAL HELP:
• Sudden severe headache with no known cause (may indicate intracranial bleed)
• Dizziness, fainting, or extreme weakness
• Swelling of the face, lips, tongue, or throat (possible allergic reaction / anaphylaxis)
• Signs of liver damage: yellowing of skin/eyes, dark urine, persistent nausea
How to use:
• Atrial Fibrillation (stroke prevention): 2.5mg or 5mg twice daily (dose determined by doctor based on age, weight, creatinine level)
• DVT/PE Treatment (initial 7 days): 10mg twice daily, then 5mg twice daily
• DVT/PE Prevention of Recurrence: 2.5mg twice daily after at least 6 months of treatment
• Post Hip/Knee Replacement Surgery: 2.5mg twice daily, starting 12–24 hours after surgery
ROUTE OF ADMINISTRATION / TIMING:
• Take at the same time(s) each day for consistent blood levels.
• Swallow tablets whole — do not crush, chew, split, or break them.
FOOD INTERACTIONS:
• Can be taken with or without food.
• No significant dietary restrictions (unlike warfarin). Avoid excessive alcohol.
MISSED DOSE:
• If you miss a dose on the same day it was due, take it as soon as you remember. If you remember the next day, skip the missed dose and continue your usual schedule. Never double up.
STORAGE:
• Store at room temperature (below 30°C / 86°F).
• Keep in original packaging, away from moisture and sunlight.
• Keep out of reach of children.
How it works:
• Eliquis 2.5mg contains Apixaban, a potent oral direct Factor Xa inhibitor.
The Coagulation Cascade:
• Blood clotting (coagulation) is a cascade of enzyme reactions. Factor Xa is a critical enzyme at the convergence of the intrinsic and extrinsic pathways — it converts prothrombin into thrombin, which then converts fibrinogen into fibrin to form a blood clot.
How Apixaban Acts:
• Apixaban works by directly and selectively binding to Factor Xa's active site, blocking its activity without requiring the cofactor antithrombin. This interrupts the coagulation cascade, preventing thrombin generation and subsequent fibrin clot formation.
KEY ADVANTAGES over warfarin:
• No routine INR/PT monitoring required
• Predictable pharmacokinetics with fixed dosing
• Fewer food interactions (no dietary vitamin K restriction)
• Rapid onset of action (peak plasma levels in 3–4 hours)
Result:
• Blood flows more freely through blood vessels, reducing the risk of dangerous clots forming in the heart, legs, or lungs.
Faq for medicine:
1.What makes Eliquis 2.5mg suitable for post-surgical clot prevention?
Eliquis 2.5mg (Apixaban 2.5mg) is specifically indicated for preventing DVT after hip or knee replacement surgery due to its targeted Factor Xa inhibition and manageable bleeding profile. Eliquis reduces the risk of post-operative clots forming in the legs or lungs without requiring injections or routine INR testing.
2.How long should Eliquis 2.5mg be taken after hip replacement surgery?
Eliquis 2.5mg is typically prescribed for 32–38 days after hip replacement surgery and for 10–14 days after knee replacement surgery, as per standard clinical guidelines. The treating orthopedic or vascular physician determines the exact duration based on the patient's recovery, mobility, and overall thrombotic risk profile.
3.Can Eliquis 2.5mg be safely used in elderly patients with AF?
Eliquis 2.5mg is often the preferred dose for elderly patients with non-valvular atrial fibrillation who meet dose-reduction criteria such as age ≥80, body weight ≤60kg, or serum creatinine ≥1.5mg/dL. Eliquis provides effective stroke prevention with a lower bleeding risk compared to full-dose anticoagulation in this population.
4.Does Eliquis 2.5mg require dietary restrictions like warfarin?
Unlike warfarin, Eliquis 2.5mg does not require dietary restrictions related to vitamin K intake. Patients can consume leafy vegetables and other foods without affecting Apixaban's anticoagulant activity. This makes Eliquis more convenient for patients who previously struggled with warfarin dietary management.
5.What happens if Eliquis 2.5mg is stopped suddenly?
Abruptly stopping Eliquis 2.5mg increases the risk of stroke or thromboembolism, particularly in patients with atrial fibrillation. If discontinuation is required for a procedure, a physician should guide the transition and bridging strategy. Eliquis should never be stopped without consulting the prescribing cardiologist or physician.
6.Is Eliquis 2.5mg the same as generic Apixaban 2.5mg?
Eliquis 2.5mg is a branded formulation of Apixaban 2.5mg developed by Bristol-Myers Squibb and Pfizer. Generic Apixaban 2.5mg contains the same active ingredient and dose. Therapeutic equivalence depends on bioavailability standards. Switching between branded and generic versions should be discussed with the prescribing physician.
Medicine interaction:
• Strong CYP3A4 + P-gp Inhibitors (increase Apixaban levels — AVOID or use with caution): Ketoconazole, itraconazole, clarithromycin, ritonavir, other HIV protease inhibitors
• Strong CYP3A4 + P-gp Inducers (decrease Apixaban levels — AVOID): Rifampicin, phenytoin, carbamazepine, phenobarbital, St. John's Wort
• Other Anticoagulants/Antithrombotics: Warfarin, heparin, clopidogrel, aspirin — concurrent use significantly increases bleeding risk; use only if medically justified with close monitoring
• NSAIDs (ibuprofen, naproxen): Increase bleeding risk when combined with Apixaban
• Antidepressants (SSRIs/SNRIs): May increase bleeding risk
VACCINE INTERACTIONS / ALCOHOL INTERACTION:
• Moderate alcohol may increase bleeding risk. Limit consumption and avoid binge drinking.
SUPPLEMENT INTERACTIONS:
• St. John's Wort: Significantly reduces Apixaban plasma levels — strictly avoid.
• Omega-3/fish oil, garlic, ginkgo, vitamin E at high doses: May enhance antiplatelet/anticoagulant effect and increase bleeding risk.
