Afogatran is an inActive pro drug that is converted to dabigatran the Active form by esterase catalyzed hydrolysis in the plasma and liver Dabigatran the main Active principle in plasma is a rapid acting competitive and reversible direct inhibitor of thrombin Thrombin a serine protease is responsible for the conversion of fibrinogen to fibrin in the coagulation cascade Inhibition of thrombin consequently prevents thrombus development Dabigatran inhibits free thrombin fibrin bound thrombin and thrombin induced platelet aggregation

If you are known to be allergic to AFOGATRAN 75MG CAPSULE 10 S or any other medicines please tell your doctor If you are pregnant or breastfeeding it is advised to consult a doctor before using AFOGATRAN 75MG CAPSULE 10 S AFOGATRAN 75MG CAPSULE 10 S is not recommended for children less than 18 years of age as the Safety and effectiveness have not been established If you have an artificial heart valve stomach ulcer kidney liver problems high blood pressure or bleeding problems inform your doctor before taking AFOGATRAN 75MG CAPSULE 10 S You should inform the doctor that you are taking AFOGATRAN 75MG CAPSULE 10 S if you are due to undergo surgery Avoid consumption of alcohol while taking AFOGATRAN 75MG CAPSULE 10 S as it may increase the risk of stomach bleeding