Samtica 250mg
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Manufactured By Samarth Life Sciences Pvt Ltd
Composition Abiraterone Acetate 250mg
RS 16705.80
MRP RS 27843.00
(40% OFF)
Includes all taxes
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( Bottle of 120 Tabs )
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Description:
Samtica 250mg Tablet (Abiraterone Acetate 250mg) is a potent androgen biosynthesis inhibitor manufactured by Samarth Life Sciences Pvt Ltd, used in the treatment of metastatic castration-resistant prostate cancer (mCRPC) and metastatic castration-sensitive prostate cancer (mCSPC) in adult men. It is a prescription-only oral anticancer medicine, widely regarded as a standard-of-care hormone therapy in advanced prostate cancer management. Available from Shabbir Medical Hall at the best price in India — 40% OFF MRP — with fast, genuine home delivery.
BENEFITS: Samtica 250mg works by selectively and irreversibly inhibiting CYP17A1 (17α-hydroxylase/C17,20-lyase), the key enzyme responsible for androgen biosynthesis in the testes, adrenal glands, and tumour tissue. By blocking this enzyme, Abiraterone dramatically reduces levels of testosterone and other androgens that fuel prostate cancer cell growth. This delivers meaningful clinical benefits — extending radiographic progression-free survival, delaying pain onset, reducing PSA levels, and improving overall survival — especially when combined with prednisone or prednisolone.
USAGE OVERVIEW: Samtica 250mg is taken orally as 4 tablets (1000mg total) once daily on an empty stomach — at least 1 hour before or 2 hours after any food. Food significantly increases Abiraterone absorption and systemic exposure, which may increase risk of side effects; therefore the empty-stomach requirement is critical. It is always used in combination with low-dose prednisone (5mg twice daily) or prednisolone to reduce risk of mineralocorticoid excess. Treatment continues until disease progression or unacceptable toxicity.
SAFETY OVERVIEW: The most important side effects include high blood pressure, fluid retention, low potassium (hypokalaemia), and elevated liver enzymes. Patients should have blood pressure, electrolytes, and liver function monitored regularly. Inform your oncologist about all medications and conditions before starting therapy. Store at room temperature, away from moisture and light.
Uses / Indications:
• Metastatic Castration-Resistant Prostate Cancer (mCRPC): in combination with prednisone, in patients previously treated with docetaxel or in chemotherapy-naive patients
• Metastatic Castration-Sensitive Prostate Cancer (mCSPC): in newly diagnosed metastatic patients, in combination with androgen deprivation therapy (ADT) and prednisone/prednisolone
• High-Risk Non-Metastatic Castration-Sensitive Prostate Cancer (with certain regimens, as per oncologist guidance)
ADDITIONAL USES:
• As part of combination hormone therapy protocols with LHRH agonists/antagonists (e.g., leuprolide, goserelin)
• Patients who have failed standard ADT and progressed to castration-resistant stage
Interactions / Warnings:
LIVER WARNING:
- Severe hepatotoxicity (including fatal liver failure) reported. Measure ALT, AST, and bilirubin before starting and every 2 weeks for the first 3 months, then monthly thereafter.
- If ALT or AST >5x ULN or bilirubin >3x ULN: interrupt treatment and consult oncologist immediately.
MINERALOCORTICOID EXCESS:
- Abiraterone increases mineralocorticoid precursors (DOC, corticosterone) due to CYP17 blockade, causing hypertension, hypokalaemia, and fluid retention.
- Prednisone co-administration is mandatory to mitigate this effect.
- Monitor blood pressure, potassium, and signs of fluid retention at every visit.
ADRENAL INSUFFICIENCY:
- Risk increases if prednisone is missed, tapered, or during periods of physiological stress (surgery, infection, trauma).
- Patients should wear a medical alert indicating steroid dependence.
CARDIOVASCULAR DISEASE:
- Use with caution in patients with significant cardiovascular conditions (heart failure, recent MI, uncontrolled arrhythmia). Assess cardiac function before and during treatment.
RENAL / HEPATIC DISEASE:
- Mild/moderate hepatic impairment: use with caution; monitor LFTs frequently.
- Severe hepatic impairment (Child-Pugh C): contraindicated.
- No specific dose adjustment for renal impairment, but limited data available.
DIABETES MANAGEMENT:
- Prednisone co-medication may worsen glycaemic control. Monitor blood glucose regularly in diabetic patients.
ELDERLY USE (>=65 years):
- No dose adjustment required, but this population carries higher baseline cardiovascular and hepatic risks; monitor closely.
Pregnancy interaction:
• Samtica 250mg is NOT indicated for use in women.
• Abiraterone Acetate is classified as potentially harmful to a developing foetus.
• Female partners of male patients being treated should use highly effective contraception during and for 3 weeks after the last dose.
• If a female partner becomes pregnant during the patient's treatment, the oncologist must be informed immediately.
• This medicine must NOT be handled by pregnant women or women of childbearing potential — contact with crushed or broken tablets must be avoided.
BREASTFEEDING:
• Not applicable — Samtica 250mg is indicated for adult males only.
• Female partners who are breastfeeding should avoid direct contact with the patient's tablets.
DOCTOR CONSULTATION WARNING:
• Never stop Samtica without consulting your oncologist. Stopping prematurely may lead to rapid disease progression and loss of clinical benefit.
Expert advice:
1. EMPTY STOMACH — NON-NEGOTIABLE:
Samtica 250mg MUST be taken on an empty stomach. Food, even a light snack, can increase abiraterone blood levels up to 10-fold with high-fat meals, dramatically increasing side effect risk. Set a consistent daily alarm at least 1–2 hours away from any meal.
2. NEVER MISS THE PREDNISONE:
Abiraterone without prednisone/prednisolone leads to dangerous mineralocorticoid excess (hypertension, hypokalaemia, fluid retention). Always take the prescribed steroid dose; carry extra supply when travelling. Inform any other doctor treating you that you are on corticosteroids.
3. MONITOR BLOOD PRESSURE AT HOME:
High blood pressure is a very common side effect. Invest in a home BP monitor; aim to keep readings below 140/90 mmHg. Report any reading consistently above 160/100 to your oncologist promptly.
4. WATCH FOR HYPOKALAEMIA SIGNS:
Low potassium causes fatigue, muscle weakness, leg cramps, and irregular heartbeat. Eat potassium-rich foods (banana, tomato, spinach) if advised by your doctor, and do NOT take potassium supplements without explicit instruction.
5. LIVER FUNCTION TESTS ARE MANDATORY:
LFTs must be checked every 2 weeks for the first 3 months. Never skip lab appointments. Report any yellowing of eyes/skin, dark urine, or persistent nausea/vomiting immediately — these signal liver toxicity.
MONITORING ADVICE:
• LFTs (ALT, AST, bilirubin): Every 2 weeks for first 3 months → monthly thereafter
• Serum electrolytes (potassium, phosphate): Monthly or as directed
• Blood pressure: Every clinical visit + home monitoring
• Blood glucose: Monthly (especially in diabetic patients on prednisone)
• PSA (Prostate Specific Antigen): Every 1–3 months to assess treatment response
• Testosterone levels: Periodic assessment of castrate levels (<50 ng/dL)
• ECG: If symptoms of cardiac arrhythmia develop
COMPLIANCE TIPS:
• Use a weekly pill organiser to track daily tablet intake
• Keep a medication diary noting dose times, BP readings, and any new symptoms
• Never crush, split, or chew tablets — swallow whole with a full glass of water
• Store in original bottle in a cool, dry place — away from bathroom humidity
• Carry your oncologist's prescription and a full medication list at all times
• Do NOT share medications — abiraterone is specific to your cancer profile
• If you are having any surgical procedure, inform the anaesthetist and surgeon about your prednisone use
SAFETY TIPS:
• Wash hands after handling tablets
• Women (including caregivers) should avoid touching crushed or broken tablets — use gloves if handling is unavoidable
• If tablet is accidentally broken, avoid inhalation of powder and wash skin/eyes with water
• Report any new chest pain, shortness of breath, or palpitations immediately
• Notify oncologist before starting any new prescription or over-the-counter medicine, including herbal supplements
Side Effects:
• Hypokalaemia (low potassium): fatigue, muscle weakness, palpitations — monitor electrolytes regularly
• Fluid retention / oedema: ankle/leg swelling, weight gain
• Hypertension (high blood pressure): monitor BP at every visit
• Elevated liver enzymes (ALT, AST): monitor LFTs, especially in first 3 months
• Fatigue and weakness
• Hot flushes / flushing (androgen suppression effect)
• Nausea, diarrhoea, dyspepsia
• Urinary tract infections
• Hyperglycaemia (especially with prednisone co-administration)
SERIOUS SIDE EFFECTS (contact your doctor immediately):
• Severe hepatotoxicity / liver failure: jaundice, dark urine, severe fatigue, right upper abdominal pain
• Severe hypokalaemia: irregular heartbeat, severe muscle cramps, paralysis
• Adrenal insufficiency: especially during stress, infection, or if prednisone is interrupted
• Cardiac disorders: heart failure, atrial fibrillation, tachycardia
• Posterior reversible encephalopathy syndrome (PRES — very rare): headache, seizure, confusion, visual changes
EMERGENCY SIGNS — SEEK IMMEDIATE MEDICAL HELP:
• Sudden yellowing of eyes/skin (jaundice)
• Irregular, fast, or slow heartbeat
• Severe lower limb swelling with breathlessness (possible cardiac failure)
• Sudden severe headache, confusion, or visual disturbance
• Signs of severe infection (fever >38°C / 100.4°F, chills, rigors)
How to use:
• Standard Dose: Abiraterone Acetate 1000mg (4 × 250mg tablets) taken ONCE daily
• Always combine with: Prednisone 5mg TWICE daily (or prednisolone as directed)
• Continuous once-daily oral therapy until disease progression or unacceptable toxicity
CRITICAL FOOD INTERACTION:
• Take on an EMPTY STOMACH — at least 1 hour BEFORE or at least 2 hours AFTER food
• Food (especially high-fat meals) dramatically increases abiraterone exposure (up to 10x with high-fat), significantly raising risk of toxicity
• Swallow tablets whole with water — do NOT crush, split, or chew
TIMING:
• Take at the same time each day, consistently on an empty stomach
• Take prednisone/prednisolone as prescribed — never skip the steroid dose
MISSED DOSE:
• If a dose is missed, take the normal dose the next day at the usual time
• Do NOT take a double dose on the same day
STORAGE:
• Store below 30°C, in a dry place away from direct sunlight and moisture
• Keep in original container with lid tightly closed
• Keep out of reach of children and pets
• Do NOT use beyond expiry date printed on bottle
How it works:
Samtica 250mg contains Abiraterone Acetate, a prodrug that is rapidly converted in vivo to Abiraterone — a selective, irreversible inhibitor of CYP17A1 (17α-hydroxylase and C17,20-lyase).
Prostate cancer cells depend on androgens (primarily testosterone and DHT) for survival and proliferation, even after surgical or medical castration, because residual androgens are produced in the adrenal glands and within tumour tissue itself.
Abiraterone blocks CYP17A1, the pivotal enzyme in androgen biosynthesis, suppressing production of:
• Testosterone and dihydrotestosterone (DHT) — primary androgen receptor (AR) agonists in prostate cancer
• DHEA and androstenedione — adrenal androgen precursors
• Cortisol — inhibited production triggers compensatory ACTH rise; prednisone co-administration prevents mineralocorticoid excess
KEY CLINICAL ADVANTAGES:
• Achieves testosterone suppression well below castrate levels (<1 ng/dL)
• Demonstrated overall survival benefit in both mCRPC and mCSPC settings in Phase III trials (COU-AA-301, COU-AA-302, LATITUDE)
• Oral once-daily dosing supports outpatient management
• Can delay chemotherapy initiation in castration-resistant disease
Faq for medicine:
Samtica 250mg (Abiraterone Acetate) is used to treat metastatic prostate cancer in adult men by reducing androgen production and slowing cancer growth. It is usually given along with prednisone.
2. How does Samtica 250mg Abiraterone Acetate Tablet work?
Abiraterone works by blocking the CYP17A1 enzyme responsible for testosterone production, helping slow the growth and survival of prostate cancer cells.
3. How should I take Samtica 250mg Tablet?
Take 4 tablets (1000mg) once daily on an empty stomach, at least 1 hour before or 2 hours after food. It should be taken with prednisone exactly as prescribed by your doctor.
4. What are the side effects of Samtica 250mg Tablet?
Common side effects include high blood pressure, low potassium, fluid retention, fatigue, and increased liver enzymes. Serious side effects may include liver toxicity, heart-related problems, and adrenal insufficiency.
5. Can I buy Samtica 250mg Tablet online at the best price in India?
Yes. Samtica 250mg Tablet can be purchased online in India with a valid prescription.
Medicine interaction:
• Strong CYP3A4 inducers (rifampicin, carbamazepine, phenytoin, St John's Wort): Significantly reduce abiraterone exposure — AVOID; if unavoidable, increase abiraterone dose (per oncologist)
• Strong CYP2D6 substrates with narrow therapeutic index (dextromethorphan, thioridazine, certain antidepressants): Abiraterone inhibits CYP2D6 — dose adjustment may be required
• Spironolactone: Competes with abiraterone at CYP17A1 — avoid combination
• Ketoconazole and strong CYP3A4 inhibitors: Increased abiraterone exposure; use with caution
• Prednisone/prednisolone: Required co-administration — do NOT omit the steroid
• Warfarin and anticoagulants: Monitor INR closely; abiraterone may affect CYP2C9 substrates
• Immunosuppressants (cyclosporine, tacrolimus): Monitor drug levels carefully
VACCINE INTERACTIONS:
• Live attenuated vaccines: Avoid during treatment due to corticosteroid co-administration (immunosuppressive effect of prednisone)
SUPPLEMENT INTERACTIONS:
• St John's Wort: Strongly induces CYP3A4 — AVOID; significantly reduces abiraterone levels
• Always inform doctor of all herbal supplements, vitamins, and over-the-counter medicines
