Revac B MCF PFS Vaccine

Revac B MCF PFS Vaccine is a recombinant Hepatitis B vaccine manufactured by Bharat Biotech International Limited, India's leading vaccine innovator. Each prefilled syringe contains 10 mcg of Hepatitis B surface antigen (HBsAg) adsorbed on aluminium hydroxide, specifically formulated for active immunisation against infection caused by all known subtypes of the Hepatitis B virus (HBV) in individuals of all age groups. Available from Shabbir Medical Hall at the best price in India, this genuine prescription vaccine is available online with fast delivery nationwide.

BENEFITS: Revac B MCF PFS Vaccine provides high-performance, long-lasting protection against Hepatitis B, a potentially life-threatening liver infection. It stimulates the body's immune system to produce protective anti-HBs antibodies, creating durable immunity against HBV. The vaccine is recommended by WHO, IAP, and global health organisations for universal immunisation of infants, children, adolescents, and adults, including healthcare workers and individuals at occupational or lifestyle risk of HBV exposure. The prefilled syringe format ensures accurate dosing, minimises contamination risk, and streamlines administration in clinical and field settings.

USAGE OVERVIEW: Revac B MCF PFS Vaccine is administered by intramuscular injection (preferably deltoid in adults; anterolateral thigh in infants). The standard adult schedule is three doses (0, 1, and 6 months). An accelerated four-dose schedule (0, 7, 21 days + 12-month booster) is available for rapid pre-exposure protection. Neonates receive the first dose within 24 hours of birth. Dosage, schedule, and site of injection are strictly as directed by the treating physician or immunisation provider.

SAFETY OVERVIEW: The most common side effects are injection site reactions (pain, redness, swelling) and mild systemic reactions (fever, fatigue, headache). Serious adverse events are rare. This vaccine is NOT for use if the patient has a known hypersensitivity to any vaccine component. Always consult your doctor before administration.

Uses / Indications:

PRIMARY USES:
• Active immunisation against Hepatitis B virus (HBV) infection in all age groups (infants, children, adolescents, adults)
• Universal infant immunisation as part of the National Immunisation Schedule (birth dose + EPI schedule)
• Pre-exposure prophylaxis in high-risk groups: healthcare workers, laboratory personnel, patients on haemodialysis, individuals with multiple sexual partners, travellers to HBV-endemic areas
• Post-exposure prophylaxis (in combination with Hepatitis B Immunoglobulin / HBIG)

ADDITIONAL USES:
• Neonates born to HBsAg-positive mothers (always combined with HBIG)
• Catch-up vaccination for unvaccinated older children and adults
• Institutional vaccination programmes: healthcare facilities, schools, defence personnel

Interactions / Warnings:

CONTRAINDICATIONS: Known hypersensitivity to any component of the vaccine (including yeast proteins). Severe febrile illness — defer vaccination until recovery.

FAINTING (SYNCOPE): Vasovagal reactions (fainting) can occur post-injection — recipients should be observed for 15 minutes after administration. Facilities for managing anaphylaxis must be immediately available.

PREMATURE INFANTS: Vaccination should not be delayed based on gestational age; administer at chronological age per schedule. May exhibit reduced immune response — anti-HBs titres should be checked.

HEPATIC / RENAL IMPAIRMENT: No dose adjustment required; consult physician in severe cases.

ELDERLY USE (≥65 years): Immunogenicity may be reduced; anti-HBs monitoring recommended post-vaccination.

COLD CHAIN INTEGRITY: NEVER use vaccine that has been frozen — freezing destroys the aluminium adjuvant structure and reduces immunogenicity. Always verify cold-chain compliance before use.

Pregnancy interaction:

PREGNANCY SAFETY:
• Animal reproductive studies do not indicate direct or indirect harmful effects.
• Hepatitis B vaccination during pregnancy is recommended by WHO when the benefit outweighs risk (e.g., high-risk healthcare workers, endemic areas).
• Consult your obstetrician before vaccination during pregnancy.

BREASTFEEDING:
• No known harmful effects. Vaccination of breastfeeding mothers is considered safe.
• Consult your doctor for individual assessment.

FERTILITY:
• No evidence of impairment of fertility.

Expert advice:

PHARMACIST BEST PRACTICES:

• 1. NEVER FREEZE THE VACCINE: Revac B MCF PFS must be stored between 2°C and 8°C. Freezing irreversibly destroys the aluminium adjuvant, rendering the vaccine ineffective — even if it appears normal after thawing. Always verify cold-chain integrity on receipt.

• 2. COMPLETE THE FULL SCHEDULE: A single dose provides partial protection only. The standard 3-dose series (0, 1, 6 months) is essential for achieving seroprotective anti-HBs titres (≥10 mIU/mL) in >95% of healthy recipients. Do not stop after 1 or 2 doses.

• 3. VERIFY SEROPROTECTION IN HIGH-RISK GROUPS: Healthcare workers, haemodialysis patients, and immunocompromised individuals should have anti-HBs titres tested 1–2 months after completing the primary series. Non-responders (titres <10 mIU/mL) may require a repeat series or higher-dose formulation.

• 4. OBSERVE FOR 15 MINUTES POST-INJECTION: Vasovagal reactions (dizziness, fainting) can occur. Advise recipients to remain seated or lying down for 15 minutes after vaccination. Ensure resuscitation equipment is available at the vaccination site.

• 5. CORRECT INJECTION TECHNIQUE: Administer by intramuscular injection ONLY — deltoid for adults, anterolateral thigh for infants. Subcutaneous or intradermal injection significantly reduces immunogenicity and should never be used as a substitute.

MONITORING ADVICE:
• Anti-HBs titre (1–2 months post-series): Routine in healthcare workers and dialysis patients
• HBsAg / HBeAg status: Neonates born to HBsAg-positive mothers should be tested at 9–18 months
• Booster doses: Not routinely recommended for immunocompetent individuals; monitor titre in high-risk groups

COMPLIANCE TIPS:
• Maintain a vaccination record card for all doses received
• Note batch number and expiry for pharmacovigilance
• Set calendar reminders for dose 2 (1 month) and dose 3 (6 months)
• If dose 2 or 3 is overdue, do NOT restart the series — continue from where you left off

SAFETY TIPS:
• Inform the vaccinating doctor of any history of egg or yeast allergy
• Inform all treating doctors that you have received / are receiving Hepatitis B vaccine
• Women who are pregnant or breastfeeding should discuss risk-benefit with their obstetrician before vaccination
• Do NOT use a syringe that has been dropped, damaged, or whose integrity is in doubt

Side Effects:

COMMON SIDE EFFECTS (>1 in 10 people):
• Injection site pain, redness, swelling, and induration
• Mild fever (≤38.5°C), fatigue, headache
• Myalgia (muscle ache), malaise
• Nausea, dizziness (mild and transient)

LESS COMMON SIDE EFFECTS (1 in 10 to 1 in 100 people):
• Moderate injection site reactions (haematoma, pruritus)
• Arthralgia (joint pain)
• Upper respiratory tract symptoms
• Lymphadenopathy (enlarged lymph nodes, rare)

SERIOUS SIDE EFFECTS (rare — contact your doctor immediately):
• Anaphylaxis / severe allergic reaction: urticaria, angioedema, bronchospasm, hypotension — DISCONTINUE and seek emergency care
• High fever (>39°C with convulsions in children): report to physician immediately
• Neurological reactions (extremely rare): paraesthesia, encephalitis

EMERGENCY SIGNS — SEEK IMMEDIATE MEDICAL HELP:
• Difficulty breathing, wheezing, throat tightness
• Swelling of face, lips, tongue
• Sudden drop in blood pressure / fainting shortly after injection

How to use:

DOSAGE GUIDANCE (always as directed by your physician / immunisation provider):

ADULT & ADOLESCENT SCHEDULE (>15 years):
• Standard: 10 mcg (0.5 mL) at 0, 1, and 6 months — 3 doses total
• Accelerated: 10 mcg at 0, 7, 21 days + booster at 12 months

INFANT & CHILDREN SCHEDULE (0–14 years):
• Birth dose within 24 hours of birth (especially if mother is HBsAg-positive)
• EPI schedule: birth, 6 weeks, 10 weeks, 14 weeks (combined with pentavalent vaccine)

ROUTE OF ADMINISTRATION:
• Intramuscular (IM) injection ONLY
• Adults & older children: deltoid muscle
• Infants & young children: anterolateral thigh
• NEVER administer intravenously or intradermally

PRE-ADMINISTRATION:
• Inspect for particulates or discolouration — do not use if present
• Shake well before use; homogeneous suspension expected
• Use immediately after opening

MISSED DOSE:
• Do not restart the series; complete the remaining doses as scheduled
• Contact your doctor for guidance on revised timing

STORAGE:
• Store between 2°C and 8°C (refrigerator); do NOT freeze
• Protect from light; keep in original carton
• Keep out of reach of children
• Do not use after expiry date printed on label

How it works:

Mechanism of Action:
Revac B MCF PFS Vaccine contains recombinant Hepatitis B surface antigen (HBsAg) produced by yeast cells (Saccharomyces cerevisiae) using recombinant DNA technology.

Upon intramuscular injection:
• The HBsAg antigen is recognised by the immune system as a foreign protein
• B-lymphocytes are activated and differentiate into plasma cells, producing anti-HBs antibodies
• Memory B-cells and T-cells are generated, providing long-term immunological memory
• Anti-HBs titres ≥10 mIU/mL are considered seroprotective

The vaccine does NOT contain live virus and CANNOT cause Hepatitis B infection.

KEY ADVANTAGES:
• Protects against all known subtypes of HBV (adw, ayw, adr, ayr)
• Seroconversion rates >95% in healthy individuals on standard schedule
• Long-duration immunity (>20 years documented in responders)
• Prefilled syringe (PFS) format: accurate dosing, needle-stick safety, no reconstitution required

Faq for medicine:

1. What is Revac B MCF PFS Vaccine used for?
Revac B MCF PFS Vaccine (Hepatitis B Vaccine 10 mcg) is used for active immunisation against Hepatitis B virus (HBV) infection in infants, children, and adults, including healthcare workers and high-risk individuals, as directed by a physician.

2. How does Revac B MCF PFS Vaccine work?
Revac B MCF PFS contains recombinant HBsAg antigen that stimulates the immune system to produce anti-HBs antibodies. It creates immunological memory, providing long-lasting seroprotection (≥10 mIU/mL) against all known HBV subtypes without containing live virus.

3. What is the dosage schedule for Revac B MCF PFS Vaccine?
Standard adult schedule: 10 mcg (0.5 mL IM) at 0, 1, and 6 months — 3 doses. Infants: birth dose + EPI schedule. Neonates of HBsAg-positive mothers: first dose within 24 hours of birth with HBIG. Always follow your physician's immunisation plan.

4. What are the side effects of Revac B MCF PFS Vaccine?
Most common: injection site pain, redness, mild fever, fatigue, and headache. Serious but rare: anaphylaxis (difficulty breathing, facial swelling — seek emergency care). Observe for 15 minutes post-injection. Report any severe or unusual reactions to your doctor.

5. Can I buy Revac B MCF PFS Vaccine online at the best price in India?
Yes. Buy Revac B MCF PFS Vaccine online from Shabbir Medical Hall at 20% OFF MRP (Rs 531.43 vs Rs 664.29 per prefilled syringe). Valid prescription required. Fast delivery across Hyderabad, Bangalore, Mumbai, Delhi, and Chennai.

Medicine interaction:

IMMUNOSUPPRESSIVE THERAPY:
• Immunosuppressants (corticosteroids, chemotherapy, biologics): may reduce vaccine immunogenicity — check anti-HBs titres post-vaccination; revaccination may be needed

CONCURRENT VACCINATION:
• Can be co-administered with other EPI vaccines (DTP, OPV, Hib, MMR) at separate injection sites using separate syringes
• Co-administration with Hepatitis B Immunoglobulin (HBIG): use separate sites; does not impair seroconversion

HAEMODIALYSIS PATIENTS:
• May require higher doses (20–40 mcg) or additional booster doses; anti-HBs monitoring essential

SUPPLEMENT INTERACTIONS:
• No known significant interactions with vitamins or dietary supplements