Although the mechanism of action of mesalazine is not fully understood, it appears to be topical rather than systemic. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e. prostanoids, and through the lipoxygenase pathways, i.e. leukotrienes and hydroxyeicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.

If you are allergic to Mesacol CR 1gm Granules or any other medicines, please tell your doctor. Mesacol CR 1gm Granules (tablet/suppository) is not recommended for children below 2 years, and Mesacol CR 1gm Granules granules are not recommended for children below 6 years. Please inform your doctor before taking Mesacol CR 1gm Granules if you are pregnant or breastfeeding. Mesacol CR 1gm Granules should be used with caution in the elderly. Avoid taking Mesacol CR 1gm Granules if you have severe kidney failure. Severe skin reactions such as toxic epidermal necrolysis (skin peeling and blistering) or Stevens-Johnson syndrome (a painful rash that spreads and blisters) can occur in some patients taking Mesacol CR 1gm Granules. Therefore, if you notice any skin reactions while taking Mesacol CR 1gm Granules, please consult a doctor immediately. If you have stomach pain or cramps, severe headache, fever or rash, stop taking Mesacol CR 1gm Granules and consult a doctor. If you have a stomach ulcer, asthma, any medical condition that can cause bleeding, liver, kidney or blood problems, inform your doctor before taking Mesacol CR 1gm Granules.