Although the mechanism of action of mesalazine is not fully understood it appears to be topical rather than systemic Mucosal production of arachidonic acid metabolites both through the cyclooxygenase pathways i e prostanoids and through the lipoxygenase pathways i e leukotrienes and hydroxyeicosatetraenoic acids is increased in patients with chronic inflammatory bowel disease and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon

If you are allergic to Mesacol CR 1gm Granules or any other medicines please tell your doctor Mesacol CR 1gm Granules tablet suppository is not recommended for children below 2 years and Mesacol CR 1gm Granules granules are not recommended for children below 6 years Please inform your doctor before taking Mesacol CR 1gm Granules if you are pregnant or breastfeeding Mesacol CR 1gm Granules should be used with caution in the elderly Avoid taking Mesacol CR 1gm Granules if you have severe kidney failure Severe skin reactions such as toxic epidermal necrolysis skin peeling and blistering or Stevens Johnson syndrome a painful rash that spreads and blisters can occur in some patients taking Mesacol CR 1gm Granules Therefore if you notice any skin reactions while taking Mesacol CR 1gm Granules please consult a doctor immediately If you have stomach pain or cramps severe headache fever or rash stop taking Mesacol CR 1gm Granules and consult a doctor If you have a stomach ulcer asthma any medical condition that can cause bleeding liver kidney or blood problems inform your doctor before taking Mesacol CR 1gm Granules