Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inActivation of incretin hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inActivated by the enzyme, DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging Active incretin levels, Vildagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Metformin: The pharmacologic mechanism of action of Metformin is different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and increases peripheral glucose uptake and utilization.

If you are allergic to Torglip OD 100 Tablet 10's or any other medicines, please tell your doctor. Torglip OD 100 Tablet 10's is not recommended for children below 18 years of age. If you are pregnant or breastfeeding, are on dailysis, please inform your doctor before taking Torglip OD 100 Tablet 10's. Avoid alcohol consumption with Torglip OD 100 Tablet 10's as it may increase or decrease blood sugar levels. Torglip OD 100 Tablet 10's is not recommended for patients with diabetic ketoacidosis and type-1 diabetes. Take short, frequent meals and avoid prolonged fasting when taking Torglip OD 100 Tablet 10's. Beware of hypoglycaemia symptoms (low blood sugar), including sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume 5-6 candies or 3 glucose biscuits or 3 teaspoons of honey/sugar and consult your doctor. Make sure to carry these with you at all times, especially during long travels. If you have type 1 diabetes, diabetic ketoacidosis (excessive levels of blood acids called ketones), disease of pancreas, kidney, liver or heart problems, inform your doctor before taking Torglip OD 100 Tablet 10's.