Each tablet contains Glimepiride (Isryl-M) 2 mg and Metformin (Isryl-M) HCl (in sustained-release form) 500 mg. It also contains the following excipients: Hypromellose, sodium carboxymethyl cellulose, methacrylic acid copolymer dispersion, macrogol, povidone, magnesium stearate, purified water, sodium starch glycolate, lactose, titanium dioxide, microcrystalline cellulose, magnesium stearate and pregelatinized starch. Colors: Yellow ferric oxide and titanium dioxide.

Some diabetic patient taking Isryl-M2 Tablet 15's may develop a serious condition called lactic acidosis. In lactic acidosis, there is too much of lactic acid accumulated in the blood. So, your liver and kidney proper functioning is required for the elimination of excess lactic acid from the blood. You should not take metformin if you have kidney disease, as measured by a blood test. Isryl-M2 Tablet 15's may lower vitamin B12 levels, so try to have blood test annual blood and vitamin. Metformin when used with insulin may extremely lower the blood sugar level. So, the doctor may lower the dose of insulin.