Canagliflozin 100mg Tablets
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Manufactured By Elder Projet
Composition Canagliflozin 100mg
RS 457.03
MRP RS 609.38
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Description:
Canagliflozin 100mg Tablet is an oral antidiabetic medicine belonging to the SGLT2 (Sodium-Glucose Co-Transporter 2) inhibitor class, manufactured by Elder Projet and used to manage blood sugar levels in adults with type 2 diabetes mellitus. Available from Shabbir Medical Hall at the best price in India, this prescription-only medicine works by promoting glucose excretion through urine, thereby lowering blood sugar independently of insulin. It is prescribed as standalone therapy or in combination with other antidiabetics such as metformin, sulfonylureas, or insulin, always alongside diet and exercise.
BENEFITS: Canagliflozin 100mg provides multiple proven benefits beyond glycaemic control. It reduces HbA1c levels, promotes modest weight loss by eliminating caloric glucose via urine, lowers blood pressure, and has demonstrated significant cardiovascular risk reduction in patients with type 2 diabetes and established cardiovascular disease. It also provides renal protective benefits, slowing the progression of diabetic kidney disease.
USAGE OVERVIEW: Take Canagliflozin 100mg exactly as prescribed by your endocrinologist or physician. The standard adult dose is 100mg once daily, taken before the first meal of the day. Your doctor may increase the dose to 300mg once daily based on your response and kidney function. Never adjust your dose without medical advice.
SAFETY OVERVIEW: The most common side effects include urinary tract infections, genital yeast infections, and increased urination. Rare but serious effects include diabetic ketoacidosis (even with near-normal blood sugar), lower-limb amputation risk, and Fournier's gangrene. Inform your doctor about kidney function, current medications, and any planned surgical procedures before starting therapy.
Uses / Indications:
• Type 2 Diabetes Mellitus (T2DM) — to improve glycaemic control in adults as an adjunct to diet and exercise.
• Cardiovascular Risk Reduction — to reduce the risk of major adverse cardiovascular events (MACE: cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke) in adults with T2DM and established cardiovascular disease.
• Diabetic Kidney Disease (DKD) — to reduce the risk of end-stage kidney disease, doubling of serum creatinine, cardiovascular death, and hospitalisation for heart failure in adults with T2DM.
COMMON / OFF-LABEL USES:
• Combination antidiabetic therapy with metformin, sulfonylureas, DPP-4 inhibitors, GLP-1 receptor agonists, or insulin.
• Weight management support in obese patients with type 2 diabetes.
• Heart failure management (off-label; increasingly used in clinical practice).
• Blood pressure reduction as an ancillary benefit in patients with T2DM.
Interactions / Warnings:
KIDNEY DISEASE:
- Do not initiate Canagliflozin if eGFR <45 mL/min/1.73m2.
- Discontinue if eGFR falls persistently below 45 (for glycaemic benefit).
- May be continued to eGFR 30 for CV/renal protection in selected patients -- consult specialist.
- Not recommended in patients on dialysis.
LIVER DISEASE:
- Use with caution in moderate hepatic impairment. Not recommended in severe hepatic impairment.
CARDIOVASCULAR:
- Proven cardiovascular benefit in T2DM patients with established CV disease (CANVAS trial).
- However, associated with increased risk of lower limb amputations -- monitor feet and peripheral circulation closely.
ALLERGY WARNING:
- Do not use if allergic to Canagliflozin or any excipients in the formulation.
ELDERLY USE (>=75 years):
- Greater risk of volume depletion, hypotension, UTIs, and falls. Assess renal function and hydration status before initiating.
DRIVING & MACHINERY:
- Canagliflozin itself does not impair alertness, but hypoglycaemia (when combined with insulin/sulfonylureas) can affect driving ability.
Pregnancy interaction:
• Canagliflozin 100mg is NOT recommended during pregnancy.
• Animal studies have shown adverse effects on kidney development during foetal stages; human data is insufficient.
• Women of childbearing potential should use effective contraception during treatment.
• Inform your doctor immediately if pregnancy is suspected or confirmed during treatment.
• The medicine should be discontinued as soon as pregnancy is confirmed — particularly during the 2nd and 3rd trimesters.
BREASTFEEDING:
• It is unknown whether Canagliflozin passes into human breast milk.
• Breastfeeding is NOT recommended while taking Canagliflozin 100mg as a precautionary measure.
• Discuss alternative feeding options with your doctor.
DOCTOR CONSULTATION WARNING:
• Never start, stop, or change Canagliflozin dosing without consulting your endocrinologist or physician.
• Stopping abruptly may cause a rebound increase in blood glucose levels.
Expert advice:
1. TAKE BEFORE BREAKFAST:
• Canagliflozin 100mg should be taken before your first meal of the day for optimal efficacy.
• Consistent morning timing helps maintain stable plasma drug levels throughout the day.
2. STAY WELL HYDRATED:
• Because Canagliflozin promotes urinary glucose excretion (glucosuria), it acts as a mild diuretic.
• Drink adequate fluids daily (6–8 glasses of water) to prevent dehydration and reduce urinary tract infection (UTI) risk.
3. MONITOR YOUR FEET REGULARLY:
• Clinical trials (CANVAS) noted an increased risk of lower-limb amputations.
• Inspect feet daily for cuts, blisters, sores, or wounds.
• Report any foot ulcers or peripheral vascular changes to your doctor immediately.
4. RECOGNISE DKA SYMPTOMS:
• Diabetic ketoacidosis (DKA) can occur even when blood sugar appears near-normal with SGLT2 inhibitors (“euglycaemic DKA”).
• Seek immediate medical help if you experience nausea, vomiting, abdominal pain, fruity breath, or difficulty breathing.
5. INFORM ALL HEALTHCARE PROVIDERS:
• Always tell your dentist, surgeon, or any other healthcare professional that you are taking Canagliflozin.
• The medicine may need to be paused before major surgeries or fasting procedures to reduce DKA risk.
Monitoring Advice
HbA1c (GLYCATED HAEMOGLOBIN):
• Every 3 months initially, then every 6 months.
• Target HbA1c is usually <7% or as directed by your diabetologist.
KIDNEY FUNCTION (eGFR / SERUM CREATININE):
• Check before starting treatment and periodically thereafter.
• Generally not recommended if eGFR is below 45 mL/min/1.73m².
LIVER FUNCTION TESTS (LFTs):
• Baseline monitoring recommended, especially in patients with hepatic risk factors.
BLOOD PRESSURE:
• Monitor regularly — Canagliflozin has a mild antihypertensive effect.
BODY WEIGHT:
• Monitor monthly — modest weight loss is a recognised therapeutic benefit.
FOOT EXAMINATION:
• Foot assessment should be performed at every clinical visit as part of diabetic foot care.
Compliance Tips
CONSISTENT DAILY USE:
• Take Canagliflozin at the same time each morning.
• Link it to a daily habit such as morning tea or breakfast.
REMINDER TOOLS:
• Use a pill organiser or set a phone alarm to improve adherence.
MEDICINE SHARING WARNING:
• Never share your prescription medicine with others — dosing is individualised.
FOLLOW-UP APPOINTMENTS:
• Keep all scheduled endocrinology and laboratory appointments.
BLOOD GLUCOSE MONITORING:
• Continue monitoring blood sugar as directed — Canagliflozin does not fully replace self-monitoring.
Safety Tips
HYPOGLYCAEMIA PRECAUTION:
• Carry glucose tablets or a sweet snack if taking Canagliflozin with insulin or sulfonylureas.
PERSONAL HYGIENE:
• Maintain good genital hygiene to reduce the risk of fungal/yeast infections.
SURGERY & FASTING WARNING:
• If undergoing surgery or prolonged fasting, inform your surgeon or physician.
• Canagliflozin may need to be stopped at least 3 days before the procedure.
SAFE DISPOSAL:
• Dispose of unused tablets through a pharmacy take-back programme.
• Do not flush medicines or discard them in household waste.
Side Effects:
• Urinary Tract Infections (UTIs) — burning sensation, frequent urination, cloudy urine.
• Genital mycotic infections (yeast infections) — itching, irritation, discharge (affects both men and women).
• Increased urination (polyuria) — due to osmotic diuresis effect.
• Thirst and dry mouth.
• Constipation and nausea.
• Hypoglycaemia — mainly when combined with insulin or sulfonylureas.
SERIOUS SIDE EFFECTS (contact your doctor immediately):
• Diabetic Ketoacidosis (DKA) — may occur even with near-normal blood glucose levels; symptoms include nausea, vomiting, abdominal pain, fruity breath, difficulty breathing, and confusion.
• Lower-Limb Amputations — increased risk observed in the CANVAS trial; regular foot monitoring is essential.
• Fournier’s Gangrene (necrotising fasciitis of the perineum) — rare but life-threatening.
• Acute Kidney Injury — especially in dehydrated or volume-depleted patients.
• Bone fractures — slight increase in fracture risk reported.
• Hypotension — due to fluid loss from the medicine’s diuretic effect.
EMERGENCY WARNING SIGNS:
• Signs of DKA: fruity breath, rapid breathing, confusion, vomiting.
• Pain, tenderness, redness, or swelling in the genital/perineal area.
• Sudden severe leg or foot pain, or wounds that do not heal.
• Signs of allergic reaction: rash, swelling of the face, lips, tongue, or throat.
How to use:
• Standard Adult Dose: 100mg once daily, taken before the first meal of the day.
• Dose Escalation: 300mg once daily may be prescribed if 100mg is insufficient and eGFR ≥60 mL/min/1.73m².
• Combination Therapy: May be prescribed together with metformin, sulfonylureas, DPP-4 inhibitors, or insulin.
• Renal Impairment: Do NOT initiate treatment if eGFR is below 45 mL/min/1.73m²; discontinue if eGFR persistently falls below 45 for glycaemic benefit.
TIMING:
• Take at the same time each day — preferably before breakfast — to maintain consistent drug levels.
• Swallow tablets whole — do not crush, chew, split, or break them.
FOOD INTERACTIONS:
• Can be taken with or without food, although taking it before the first meal is recommended.
• Avoid excessive high-carbohydrate intake and follow your prescribed diabetic meal plan.
• Avoid excessive alcohol consumption.
MISSED DOSE:
• If you miss a dose, take it as soon as you remember on the same day.
• If it is already the next day, skip the missed dose and continue your regular schedule.
• Never take a double dose to make up for a missed tablet.
STORAGE:
• Store at room temperature (below 30°C / 86°F).
• Keep tablets in the original packaging, protected from moisture and direct sunlight.
• Keep out of reach of children.
How it works:
Under normal physiological conditions, the kidneys filter glucose from the blood and reabsorb nearly all of it through SGLT2 transporters located in the proximal tubule. In type 2 diabetes, blood glucose remains chronically elevated due to insulin resistance and/or insufficient insulin secretion.
Canagliflozin works by selectively blocking SGLT2 transporters in the kidney proximal tubule, preventing glucose reabsorption and causing excess glucose to be excreted through urine (glucosuria). This lowers blood glucose levels independently of insulin action.
KEY ADVANTAGES:
• Insulin-independent action — works regardless of insulin sensitivity.
• Low risk of hypoglycaemia when used as monotherapy.
• Modest weight loss (approximately 1–3 kg) through urinary caloric loss.
• Mild blood pressure reduction due to osmotic diuresis.
• Proven cardiovascular and renal protective effects demonstrated in the CANVAS and CREDENCE clinical trials.
RESULT:
• Lower blood glucose levels.
• Reduced HbA1c.
• Protective benefits for the heart and kidneys.
Faq for medicine:
Canagliflozin 100mg treats type 2 diabetes by lowering blood sugar. It also reduces the risk of heart attack, stroke, and slows diabetic kidney disease in adults.
2. How does Canagliflozin 100mg work?
Canagliflozin 100mg works by helping the kidneys remove excess sugar from the body through urine, which lowers blood sugar levels.
3. What is the dose of Canagliflozin 100mg?
Take 100mg once daily before your first meal. Your doctor may increase it to 300mg if needed and kidney function is adequate. Do not adjust the dose without medical advice.
4. What are the side effects of Canagliflozin 100mg?
Common side effects include increased urination, urinary tract infections, genital fungal infections, dehydration, dizziness, and low blood sugar when used with other diabetes medicines.
5. Can I buy Canagliflozin 100mg online in India?
Yes. A valid prescription is required to buy Canagliflozin 100mg online in India.
Medicine interaction:
• Insulin & Sulfonylureas: Combined use increases hypoglycaemia risk — dose reduction may be required.
• Diuretics (furosemide, hydrochlorothiazide/HCTZ): Additive volume depletion may increase the risk of dehydration, hypotension, and acute kidney injury.
• NSAIDs (ibuprofen, naproxen): May impair renal function when combined with Canagliflozin — avoid or monitor closely.
• Rifampicin and other UGT inducers: Can significantly reduce Canagliflozin plasma levels and decrease efficacy.
• Digoxin: Canagliflozin may increase plasma digoxin levels — monitoring is recommended.
• ACE Inhibitors / ARBs: Combined use may increase the risk of acute kidney injury and hyperkalaemia.
• Lithium: Canagliflozin may increase lithium concentration — monitor lithium levels carefully.
ALCOHOL INTERACTION:
• Alcohol may increase the risk of hypoglycaemia and worsen dehydration/volume depletion. Limit or avoid alcohol consumption.
SUPPLEMENT INTERACTIONS:
• Herbal glucose-lowering supplements (bitter melon, fenugreek): May enhance the hypoglycaemic effect — use cautiously.
• High-dose Vitamin C: May interfere with urine glucose test results.
