Diclofenac (Esgipyrin) reduces joint pain at rest and in motion, as well as morning stiffness and swelling of the joints, helps to increase range of motion; reduces post-traumatic and postoperative pain, and inflammatory edema. Inhibits platelet aggregation. With prolonged use has a desensitizing effect. When used topically in ophthalmology reduces swelling and pain in inflammatory processes non-infectious etiology.

Esgipyrin Tablet 15's is shown to interact with various drugs. Some of them include pain killers (naproxen, aspirin, ibuprofen, tramadol, hydrocodone, oxycodone), antibiotics (ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin or ofloxacin), diuretics (furosemide and bumetanide), medicines for heart problems or medicines for high blood pressure (digoxin), medicines used to lower cholesterol (colestipol and cholestyramine), medicines to treat seizures (phenytoin), medicines that reduce the Activity of your immune system (ciclosporin or tacrolimus), steroid medicines (hydrocortisone or prednisolone), blood thinner (warfarin), anti-depressant (duloxetine) and acidity lowering drugs (cimetidine). These drugs may affect the working of Esgipyrin Tablet 15's and may alter its efficacy.