Calpol 6 Plus exhibits analgesic action by peripheral blockage of pain impulse generation It produces antipyresis by inhibiting the hypothalamic heat regulating centre Its weak anti inflammatory Activity is related to inhibition of prostaglandin synthesis in the CNS Calpol 6 Plus Acetaminophen is thought to act primarily in the CNS increasing the pain threshold by inhibiting both isoforms of cyclooxygenase COX 1 COX 2 and COX 3 enzymes involved in prostaglandin PG synthesis Unlike NSAIDs acetaminophen does not inhibit cyclooxygenase in peripheral tissues and thus has no peripheral anti inflammatory affects While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme s Active site studies have found that acetaminophen indirectly blocks COX and that this blockade is ineffective in the presence of peroxides This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX 1 and COX 2 This enzyme is now referred to as COX 3 Its exact mechanism of action is still poorly understood but future research may provide further insight into how it works The antipyretic properties of acetaminophen are likely due to direct effects on the heat regulating centres of the hypothalamus resulting in peripheral vasodilation sweating and hence heat dissipation

Consult your doctor immediately if you develop any allergic reactions such as skin rash swelling of face lips tongue throat wheezing or shortness of breath Do not take it if you have any known allergy to paracetamol People with kidney diseases liver disease heart disease allergic skin problems or breathing problems should avoid taking Calpol 250 mg Oral Suspension 60 ml People who are dehydrated for a long time should avoid intake of Calpol 250 mg Oral Suspension 60 ml If you have a low sodium level in the body first consult with the doctor before intake of Calpol 250 mg Oral Suspension 60 ml People who are heavy alcoholic drinkers alcohol addict should consult a doctor and avoid a Calpol 250 mg Oral Suspension 60 ml intake Do not take Calpol 250 mg Oral Suspension 60 ml if you have persistent headache problem Calpol 250 mg Oral Suspension 60 ml is not recommended for use in the children less than 2 months of age groups