It is a direct smooth muscle relaxant which have a prominent action vascular smooth muscles preferentially veins than arteries It is enzymatically denitrated in the smooth muscle cells to release the reActive free radical nitric oxide which Activates cytosolic guanylyl cyclase thus increases cyclic GMP levels which causes dephosphorylation of myosin light chain kinase MLCK through a cyclic GMP dependent protein kinase Reduced availability of phosphorylated Active MLCK interferes with Activation of myosin and myosin fails to interact with actin to cause contraction and consequently relaxation occurs Elevated levels of cyclic GMP also reduce calcium entry which also contributing to relaxation It dilates veins more than arteries because veins have greater amount of enzyme that generate nitric oxide from nitrates It also preferentially dilates epicardial arteries than autoregulatory arteries duo to defferential distribution of nitrate metabolizing enzymes in these vessels

Do not take Sorbitrate 10 Tablet 50 s if you are allergic to isosorbide dinitrate or its contents Do not take it if you have severe low blood pressure bleeding or increased pressure in the brain severe dehydration heart valve problems inflammation of the heart wall high blood pressure due to long term lung disease and severe anaemia Before taking Sorbitrate 10 Tablet 50 s inform your doctor if you have glaucoma increased pressure in the eye glucose 6 phosphate dehydrogenase deficiency a type of anaemia underActive thyroid hypothyroidism kidney or liver problems head injury hypothermia low body temperature or intolerance to some sugars This medicine should not be used with medicines used for erectile dysfunction like sildenafil or tadalafil Inform your doctor if you are pregnant or breastfeeding