Eliquis 5mg Tablet
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Manufactured By Bms India Pvt Ltd
Composition Apixaban 5mg
RS 432.70
MRP RS 509.06
(15% OFF)
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( 20 tablets in 1 packet )
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Description:
Eliquis 5mg Tablet (Apixaban 5mg) is an oral anticoagulant (blood thinner) belonging to the class of direct Factor Xa inhibitors, manufactured by BMS India Pvt Ltd (Bristol-Myers Squibb / Pfizer) and used to prevent and treat life-threatening blood clots in adults. It is prescribed to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation (irregular heartbeat), and to prevent and treat deep vein thrombosis (DVT) and pulmonary embolism (PE). It is also used after elective hip or knee replacement surgery to reduce clot formation risk. Available from Shabbir Medical Hall at the best price in India, this genuine prescription medicine is easy to order online with fast home delivery.
BENEFITS: Eliquis 5mg works by selectively blocking Factor Xa — a pivotal enzyme in the blood coagulation cascade — preventing the conversion of prothrombin to thrombin and, ultimately, stopping clot formation. Unlike older anticoagulants such as warfarin, Eliquis 5mg does not require routine blood monitoring (PT-INR tests), offers predictable pharmacokinetics, and has fewer food interactions, making it a preferred choice in modern cardiovascular care. The 5mg dose is the standard maintenance dose for most adult AF patients who do not meet dose-reduction criteria.
USAGE OVERVIEW: Take Eliquis 5mg exactly as prescribed by your cardiologist or physician. For most adults with atrial fibrillation, the standard dose is 5mg twice daily. For DVT/PE treatment, 10mg twice daily for 7 days followed by 5mg twice daily. Swallow tablets whole with or without food at the same time each day. Never stop treatment without consulting your doctor as this significantly increases the risk of stroke or clot recurrence.
SAFETY OVERVIEW: The most common side effect is an increased tendency to bleed (bruising, nosebleeds). Serious effects such as major bleeding episodes, blood in stools or urine, or sudden severe headache require immediate medical attention. Inform your doctor about all current medications, liver or kidney conditions, and pregnancy status before starting therapy.
Uses / Indications:
• Non-valvular Atrial Fibrillation (AF) — standard 5mg twice daily dose for stroke and systemic embolism prevention
• Deep Vein Thrombosis (DVT) — treatment (10mg twice daily × 7 days, then 5mg twice daily) and prevention of recurrence
• Pulmonary Embolism (PE) — treatment and prevention of recurrence
• Prevention of DVT/PE after elective hip or knee replacement surgery
COMMON / OFF-LABEL USES:
• Secondary prevention of cardiovascular events in selected high-risk patients
• Management of venous thromboembolism (VTE) in cancer patients (off-label in select protocols)
• Standard-dose AF regimen (5mg twice daily) in patients NOT meeting dose-reduction criteria (age <80, weight >60kg, creatinine <1.5mg/dL)
Interactions / Warnings:
LIVER DISEASE: Eliquis 5mg is NOT recommended in patients with severe hepatic impairment or liver disease associated with coagulopathy. Patients with mild to moderate liver disease should use with caution — consult doctor.
KIDNEY DISEASE: Use with caution in patients with moderate to severe renal impairment (CrCl <25 ml/min or eGFR <15). Not recommended in patients on dialysis — consult your nephrologist.
HEART CONDITIONS: Eliquis 5mg is primarily used in AF patients — it replaces warfarin in many cases. Patients with prosthetic (mechanical) heart valves should NOT use Eliquis; warfarin is preferred.
ALLERGY WARNING: Do not use Eliquis 5mg if you are allergic to Apixaban or any excipients in the formulation.
ELDERLY USE (≥75 years): Use with caution in elderly patients — dose reduction to 2.5mg twice daily applies if patient meets at least two of three criteria: age ≥80, weight ≤60kg, creatinine ≥1.5mg/dL. Patients on the 5mg dose do not meet these combined criteria.
DRIVING & MACHINERY: Eliquis may cause dizziness or fainting (from hypotension or anaemia-related weakness). Patients should assess their response before driving.
Pregnancy interaction:
• The effects of Apixaban on pregnancy and the unborn baby are not fully established.
• Eliquis 5mg is generally NOT recommended during pregnancy due to potential risk of fetal harm (possible haemorrhage, teratogenicity based on animal studies).
• Women of childbearing potential should use effective contraception during treatment.
• Inform your doctor immediately if pregnancy is suspected or confirmed during treatment.
BREASTFEEDING:
• It is not known if Apixaban passes into human breast milk.
• Breastfeeding is NOT recommended while taking Eliquis 5mg as a precautionary measure.
• Discuss alternative feeding options with your doctor.
DOCTOR CONSULTATION WARNING:
• Never start, stop, or change Eliquis dosing without consulting your cardiologist or physician. Stopping abruptly significantly increases stroke risk in AF patients.
Expert advice:
1. NEVER STOP ABRUPTLY:
• Stopping Eliquis 5mg suddenly without medical guidance significantly increases your risk of stroke or clot recurrence, especially if you have atrial fibrillation. Always consult your cardiologist before making any changes.
2. CONSISTENT TWICE-DAILY TIMING:
• Take your doses approximately 12 hours apart (e.g., 8 AM and 8 PM) every day for stable plasma drug levels and maximum efficacy.
3. NO ROUTINE BLOOD MONITORING NEEDED:
• Unlike warfarin, Eliquis 5mg does not require regular INR/PT blood tests. However, periodic kidney and liver function checks are still recommended by your doctor.
4. BLEEDING PRECAUTIONS:
• Inform all healthcare providers (dentists, surgeons, emergency doctors) that you are on Apixaban 5mg before any procedure. Carry a medication alert card or use a medical ID bracelet.
5. DOSE AWARENESS:
• The 5mg twice-daily dose is the standard dose for most AF patients. Do not reduce to 2.5mg on your own — dose reduction must be confirmed by your doctor based on specific clinical criteria (age, weight, creatinine).
6. REPORT ALL MEDICINES:
• Always inform your cardiologist and pharmacist about every medicine, supplement, or herbal product you are taking before starting Eliquis 5mg.
MONITORING ADVICE:
• Kidney function (serum creatinine / eGFR): At baseline and at least annually — dose adjustment thresholds depend on renal function.
• Liver function tests (LFTs): Baseline and periodically; Apixaban is contraindicated in significant hepatic impairment.
• Full Blood Count (FBC/CBC): If symptoms of anaemia appear (fatigue, pallor, shortness of breath).
• Blood pressure monitoring: Hypertension increases stroke risk even on anticoagulants.
COMPLIANCE TIPS:
• Store tablets in original child-proof packaging in a cool, dry location.
• Use a pill organiser or phone alarm to remember twice-daily doses.
• Never share your prescription medicine with others.
• Keep all scheduled cardiology follow-up appointments.
• Do not take OTC pain relievers (ibuprofen, aspirin) without consulting your doctor — they significantly increase bleeding risk with Apixaban.
SAFETY TIPS:
• Use a soft-bristle toothbrush and electric razor to minimise bleeding from minor cuts.
• Avoid contact sports and activities with high injury risk.
• If you cut yourself and bleeding does not stop within 10 minutes of direct pressure, seek medical attention.
• Dispose of unused tablets through a pharmacy take-back programme — never flush or bin them.
Side Effects:
• Increased tendency to bleed (bruising, nosebleeds, bleeding gums)
• Anaemia (low red blood cell count — fatigue, pallor, weakness)
• Haematoma (collection of blood under the skin)
• Nausea and mild dizziness
• Low blood pressure (hypotension)
• Skin rash
SERIOUS SIDE EFFECTS (contact your doctor immediately):
• Major bleeding episodes — blood in vomit, stools (black/tarry stools), or urine (pink/red/brown urine)
• Coughing up blood
• Intracranial/spinal haemorrhage — sudden severe headache, vision changes, confusion, weakness
• Retroperitoneal or intra-abdominal bleeding — persistent abdominal pain
• Severe bruising or unusual swelling
EMERGENCY WARNING SIGNS — SEEK IMMEDIATE MEDICAL HELP:
• Sudden severe headache with no known cause (may indicate intracranial bleed)
• Dizziness, fainting, or extreme weakness
• Swelling of the face, lips, tongue, or throat (possible allergic reaction / anaphylaxis)
• Signs of liver damage: yellowing of skin/eyes, dark urine, persistent nausea
How to use:
• Atrial Fibrillation (stroke prevention — standard dose): 5mg twice daily (unless dose reduction to 2.5mg applies)
• DVT/PE Treatment (initial 7 days): 10mg twice daily, then 5mg twice daily
• DVT/PE Prevention of Recurrence (after 6+ months treatment): may step down to 2.5mg twice daily
• Post Hip/Knee Replacement Surgery: 2.5mg twice daily starting 12–24 hours after surgery
TIMING:
• Take at the same time(s) each day for consistent blood levels.
• Swallow tablets whole — do not crush, chew, split, or break them.
FOOD INTERACTIONS:
• Can be taken with or without food.
• No significant dietary restrictions (unlike warfarin). Avoid excessive alcohol.
MISSED DOSE:
• If you miss a dose on the same day it was due, take it as soon as you remember. If you remember the next day, skip the missed dose and continue your usual schedule. Never double up.
STORAGE:
• Store at room temperature (below 30°C / 86°F).
• Keep in original packaging, away from moisture and sunlight.
• Keep out of reach of children.
How it works:
Eliquis 5mg contains Apixaban, a potent oral direct Factor Xa inhibitor.
Blood clotting (coagulation) is a cascade of enzyme reactions. Factor Xa is a critical enzyme at the convergence of the intrinsic and extrinsic pathways — it converts prothrombin into thrombin, which then converts fibrinogen into fibrin to form a blood clot.
Apixaban works by directly and selectively binding to Factor Xa's active site, blocking its activity without requiring the cofactor antithrombin. This interrupts the coagulation cascade, preventing thrombin generation and subsequent fibrin clot formation.
Key advantages over warfarin:
• No routine INR/PT monitoring required
• Predictable pharmacokinetics with fixed dosing
• Fewer food interactions (no dietary vitamin K restriction)
• Rapid onset of action (peak plasma levels in 3–4 hours)
The result: blood flows more freely through blood vessels, reducing the risk of dangerous clots forming in the heart, legs, or lungs.
Faq for medicine:
Eliquis 5mg (Apixaban 5mg) is primarily prescribed for stroke and systemic embolism prevention in adults with non-valvular atrial fibrillation. It is also used to treat acute deep vein thrombosis (DVT) and pulmonary embolism (PE), as well as to reduce the risk of recurrent thromboembolic events after initial treatment.
2.How does Eliquis 5mg compare to rivaroxaban for DVT treatment?
Both Eliquis 5mg (Apixaban) and rivaroxaban are direct oral Factor Xa inhibitors used for DVT treatment. Clinical studies suggest Eliquis has a comparable efficacy profile with a potentially lower gastrointestinal bleeding risk compared to rivaroxaban. The choice between them depends on physician preference and patient-specific factors.
3.Can Eliquis 5mg be used by patients with liver disease?
Eliquis 5mg is contraindicated in patients with severe hepatic impairment. Since Apixaban is metabolized partly by the liver, significant liver disease can alter drug levels unpredictably and increase bleeding risk. Patients with mild to moderate liver impairment should use Eliquis 5mg with caution under specialist supervision.
4.What signs of bleeding should Eliquis 5mg patients watch for?
Patients taking Eliquis 5mg should watch for signs of abnormal bleeding including blood in urine (pink or dark urine), red or black stools, unusual bruising, prolonged bleeding from cuts, coughing up blood, or severe headaches suggesting intracranial bleeding. Seek emergency medical care if any of these symptoms occur.
5.Is Eliquis 5mg safe to use with aspirin for heart disease?
Combining Eliquis 5mg with aspirin increases the risk of bleeding and is generally avoided unless specifically indicated by a cardiologist. In selected patients with acute coronary syndrome or stent placement, dual therapy may be considered under strict medical supervision. Self-combining Eliquis with aspirin is not recommended.
6.Can Eliquis 5mg be crushed or split for patients who have difficulty swallowing?
Eliquis 5mg tablets may be crushed and mixed with water or apple juice if a patient cannot swallow tablets whole, according to prescribing information. However, patients should confirm this with their physician or pharmacist. Crushed Eliquis must be taken immediately and cannot be stored for later use.
Medicine interaction:
• Strong CYP3A4 + P-gp Inhibitors (increase Apixaban levels — AVOID or use with caution): Ketoconazole, itraconazole, clarithromycin, ritonavir, other HIV protease inhibitors
• Strong CYP3A4 + P-gp Inducers (decrease Apixaban levels — AVOID): Rifampicin, phenytoin, carbamazepine, phenobarbital, St. John's Wort
• Other Anticoagulants/Antithrombotics: Warfarin, heparin, clopidogrel, aspirin — concurrent use significantly increases bleeding risk; use only if medically justified with close monitoring
• NSAIDs (ibuprofen, naproxen): Increase bleeding risk when combined with Apixaban
• Antidepressants (SSRIs/SNRIs): May increase bleeding risk
ALCOHOL INTERACTION:
• Moderate alcohol may increase bleeding risk. Limit consumption and avoid binge drinking.
SUPPLEMENT INTERACTIONS:
• St. John's Wort: Significantly reduces Apixaban plasma levels — strictly avoid.
• Omega-3/fish oil, garlic, ginkgo, vitamin E at high doses: May enhance antiplatelet/anticoagulant effect and increase bleeding risk.
Available Substitutes
