Acitrom is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, XI and X, and interferes with coagulation. Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients on Acitrom are prohibited from giving blood.

Indigestion medicines known as proton pump inhibitors like omeprazole should be used with caution while taking Acitrom 4 Tablet 30's. Prolonged use of Acitrom 4 Tablet 30's can cause bleeding problems (like nosebleeds, heavier periods, bleeding gums, and easy bruising). If you are going to have any surgery, discontinue taking Acitrom 4 Tablet 30's 5 days before the surgery. Discontinuation of Acitrom 4 Tablet 30's might increase the risk of heart attack, stroke, and other risks of cardiovascular events. So, do not stop taking Acitrom 4 Tablet 30's of a sudden on your own decision. If you have had any recent stroke or heart attack, stop the intake of Acitrom 4 Tablet 30's with painkillers like aspirin or ibuprofen as it can increase your stomach or gastrointestinal bleeding. Purpura (blood leakage under the skin) has been observed with the use of Acitrom 4 Tablet 30's including fatal cases. If you are pregnant or planning for pregnancy or a nursing mother tell tour doctor that you are taking Acitrom 4 Tablet 30's.