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Sofosbuvir Ledipasvir

Class and Mechanism:
Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase-the key enzyme mediating HCV RNA replication. The triphosphate form of Sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

There are two main ingredients that make up Hepcinat-LP, a medication that is prescribed to help people that have been diagnosed with Hepatitis C. Those two ingredients are Sofosbuvir and Ledipasvir, and how they help specifically is they help to stop Hepatitis C cells from multiplying.

 

Dosing:

Ledipasvir-Sofosbuvir (90 mg/400 mg) is a fixed-dose combination tablet. The recommended dosage is one tablet once daily, with or without food.

  • For patients with mild to moderate renal impairment, no dosage adjustment of Ledipasvir-Sofosbuvir is recommended. There are insufficient data regarding the safety and efficacy of Ledipasvir-Sofosbuvir in patients with severe renal impairment (eGFR less than 30 ml/min/1.73m2) or end-stage renal disease requiring dialysis. Thus, no dosage recommendation has been given for patients with severe renal impairment or end-stage renal disease requiring dialysis.
  • For patients with mild, moderate, or severe hepatic impairment (Child-Pugh Class A, B, or C), no dosage adjustment is recommended, but the safety and efficacy of Ledipasvir-Sofosbuvir in patients with decompensated cirrhosis has not been established.

 

Major Drug Interactions:

Ledipasvir-Sofosbuvir has significant drug-drug interactions with P-gp inducers (e.g., St. John's wort and rifampin). The concomitant use of Ledipasvir-Sofosbuvir with P-gp inducers is not recommended. Additional drug-drug interactions may occur with Ledipasvir-Sofosbuvir and other medications.

In case of a missed dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. And I case of overdosing, seek emergency medical attention.

 

WHEN TO USE SOFOSBUVIR / LEDIPASVIR?

Sofosbuvir / Ledipasvir has been invented to fight chronic hepatitis C and to be used as a peroral combination anti-virus therapy. The medicine can be successfully administered to HIV-coinfected patients with cirrhosis. In certain cases Sofosbuvir / Ledipasvir may be prescribed for the medical treatment of patients who can’t be treated with Interferon for any reason.

 

When not to use SOFOSBUVIR / LEDIPASVIR?

If you are a woman, do not take ribavirin if you are pregnant. If you are a man, do not take ribavirin if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin. It is not known whether Ledipasvir and Sofosbuvir passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. However, it is not approved for anyone less than 18 years old.

 

Common Sofosbuvir / Ledipasvir side effects may include:

  • weakness;
  • headache; or
  • tired feeling

Get emergency medical help if you have signs of an allergic reaction to Sofosbuvir / Ledipasvir: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

 

If you also take a heart medication called amiodarone, call your doctor at once if you have:

  • extreme tiredness;
  • unusual weakness or lack of energy;
  • confusion or memory problems;
  • a light-headed feeling, like you might pass out;
  • slowed breathing; or
  • chest pain, slow heartbeats, weak pulse.

We recommend that you visit a doctor before you make your Hepcinat LP buy online. Your doctor should agree to prescribe this medication based on your symptoms, medical history and answers to a few specific questions, including any other medications you’re currently taking at the time.

With the help of Shabbir Medical Hall, you can order Hepcinat tablets for a fraction of the cost. Majority of molecules are synthesised and packaged in Hong Kong, and after being tested (this is a very important step to guarantee high-quality products) are distributed all over the world. Now patients can get Hepatitis C medications delivered to their doorsteps within 2-3 weeks. Not a single person needs to die anymore because of the lack of treatment

Sofosbuvir and Ledipasvir is widely exported and distributed wholesale in Panama, Costa Rica, Azerbaijan and many other countries along with other pharma products 

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