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Sofosbuvir

Generic Name: Sofosbuvir
Brand Name: Sovaldi
Indian Brand: Hepcinat
Manufacturer: Natco Pharma Ltd.
SOFOSBUVIR is a uridine monophosphate analogue inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.

Sofosbuvir is a white to off-white crystalline solid with a solubility of ≥ 2 mg/mL across the pH range of 2-7.7 at 37 °C and is slightly soluble in water.

 

Mode of action

Generic Sovaldi Sofosbuvir 400 mg tablets combats Hepatitis C by preventing the multiplication of the virus within the human body. Chronic Hepatitis C is treated by using Sofosbuvir 400 mg in combination with other anti-viral medications (usually ribavirin)

Sofosbuvir is a direct-acting antiviral agent (pan-genotypic polymerase inhibitor) against the hepatitis C virus. HCV RNA replication is mediated by a membrane-associated multiprotein replication complex. The HCV polymerase (NS5B protein) is an RNA-dependent RNA polymerase (RdRp). It is the essential initiating and catalytic subunit of this replication complex and is critical for the viral replication cycle. There is no human homolog for HCV NS5B RdRp. Sofosbuvir is a monophosphorylated pyrimidine nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203). GS-461203 competes with natural nucleotides for incorporation (by HCV NS5B) into the nascent RNA strand during replication of the viral genome. GS-461203 differs from endogenous pyrimidine nucleotides in that it has been modified at the 2' position with the addition of a methyl and a fluoro functional group. Incorporation of GS-461203 into nascent RNA strongly reduces the efficiency of further RNA elongation by RdRp, resulting in premature termination of RNA synthesis. The stopping of viral replication leads to a rapid decline of HCV viral load and clearing of HCV levels in the body.

 

Taking SOLVADI

SOVALDI tablets are for oral administration. Each tablet contains 400 mg of Sofosbuvir. The tablets include the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, mannitol, and microcrystalline cellulose. The tablets are film-coated with a coating material containing the following inactive ingredients: polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide, and yellow iron oxide

 

HEPATITIS C CURE MEDICATION

According to the FDA, Sovaldi is the first medication that is both safe and effective in the treatment of Chronic Hepatitis C (CHC). Since generic Sovaldi Sofosbuvir 400 mg may not make use of the patented Sovaldi name, the generic formulation is being marketed under the name Hepcinat.

During pharmaceutical trials, Sovaldi Sofosbuvir / Hepcinat proved effective in the treatment of hepatitis 1, 2, 3 and 4 as well as in patients with liver cancer who are awaiting transplants. It also proved effective in patients who have a combination of Hepatitis and HIV.

 

PRECAUTIONS FOR TAKING SOFOSBUVIR 400 MG

If you suffer from any of the following, it is essential to consult with your doctor regarding the safety of generic Sovaldi Sofosbuvir 400mg: liver problems other than hepatitis, a previous liver transplant or an HIV infection. Couples who are attempting to conceive and pregnant women must not use generic Sovaldi Sofosbuvir 400mg since it may cause birth defects or miscarriages. Breast feeding should be avoided if Sovaldi Sofosbuvir is being used.

 

Storage Conditions

Store at room temperature below 30 deg C (86 deg F)

 

SIDE EFFECTS:

The most common side effects associated with Sofosbuvir treatment are: fatigue, headache, nausea, insomnia, anaemia, and itching.

Other side effect include: Decreased appetite, diarrhoea, irritability, rash, muscle pain, flu-like symptoms, reduced blood cells, severe depression, and increases in bilirubin levels.

 

BUY GENERIC SOVALDI

Since the production of Generic Sovaldi, Sofosbuvir 400 mg has so far only been approved in India, the only way for people elsewhere in the world to obtain it is to purchase it through a reputable online SHABBIR MEDICAL HALL pharmacy that is able to acquire and distribute Generic Sovaldi Sofosbuvir 400 mg from source.

With the help of Shabbir Medical Hall, you can order Sofosbuvir, Ledipasvir and Daclatasvir pills or powders for a fraction of the cost. Majority of molecules are synthesised and packaged in Hong Kong, and after being tested (this is a very important step to guarantee high-quality products) are distributed all over the world. Now patients can get Hepatitis C medications delivered to their doorsteps within 2-3 weeks. Not a single person needs to die anymore because of the lack of treatment.

 

Why patients trust Shabbir Medical Hall?

Everybody should take a healthy measure of consideration when buying medicine over the internet. In Hepatitis C treatment area, many Sofosbuvir distributors have arisen who sell Sofosbuvir pills - and usually they are scam. Either the product they advertise in not authentic or it is not properly analysed to confirm the presence of Sofosbuvir in Sofosbuvir pills.

Shabbir Medical Hall warns against such shady distributors. We only pick the manufacturers and distribution channels that were tested time and time again. NMR scanning have been employed to test the Sofosbuvir pills created by manufacturers. The pills from selected manufacturers were given a certificate of authenticity and have helped over 1,000s of patients across the world. Allow Shabbir Medical Hall to help you as well.

 

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