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Daclatasvir

Brand Name: Daklinza
Indian Brand: Natdac
Manufacturer: Natco Pharma Ltd.
Daclatasvir (Daclatasvir systemic) is a member of the drug class NS5A inhibitors and is used to treat hepatitis C.

 

The drug can now be used in combination with Sofosbuvir (Sovaldi, Gilead Sciences), with or without ribavirin, to treat patients with HCV genotypes 1 and 3, the company’s spokesman said in a news release.

"The expanded indication for Daklinza offers an additional treatment option for multiple subsets of patients who have genotype 1 or 3 chronic HCV,"

NS5A is an essential component for hepatitis C virus (HCV) replication complex. Daclatasvir (BMS-790052; EBP 883)has broad genotype coverage and exhibits picomolar in vitro potency against genotypes 1a (EC50 50pm) and 1b (EC50 9pm).Daclatasvir (BMS-790052; EBP 883) produces a robust decline in HCV RNA (-3.6 logs after 48 hours from a single 100 mg) dose following a single dose in patients chronically infected with HCV genotype 1.

 

Foreign Names

  • Daclatasvirum (Latin)
  • Daclatasvir (German)
  • Daclatasvir (French)
  • Daclatasvir (Spanish)

 

Generic Names

  • Daclatasvir (OS: USAN)
  • UNII-LI2427F9CI (IS)
  • Daclatasvir Dihydrochloride (OS: USAN, JAN)
  • UNII-50ZO25C11D (IS)
  • Daclatasvir Hydrochloride (PH: JP XVI)

 

Brand Names

  • Daklinza
    Bristol-Myers Squibb, France; Bristol-Myers Squibb, Germany; Bristol-Myers Squibb, United Kingdom

 

Uses and Side effects of Daclatasvir

Daclatasvir is used with another antiviral medication (Sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without Sofosbuvir. Daclatasvir and Sofosbuvir may also be used with another antiviral medication (ribavirin). These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Cardiac Disorders: Serious symptomatic bradycardia has been reported in patients taking amiodarone who initiate treatment with Sofosbuvir in combination with another HCV direct-acting antiviral, including DAKLINZA

 

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