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Sorafenib

Active substance: Sorafenib
Brand: Nexavar
Indian Brand: Sorafenat
Manufacturer: Natco Pharma Ltd.
Dosage: 200 mg
Type of packaging: 120 tab / 30 tab
Nexavar is an oral highly effective targeted chemotherapy of a new generation, which is based on an active substance Sorafenib. Nexavar is approved for the treatment of hepatocellular carcinoma (HCC) as well as for patients with advanced renal cell carcinoma (RCC). While receiving Nexavar, a considerable (44%) increase in overall survival has been proven in patients with HCC or primary liver cancer, as well as 56% decrease in risks of disease progression.

 

Mode of action

Sorafenib (Nexavar) is a small molecule multi-kinase inhibitor with mechanism of action based on inhibition of intracellular kinases (B-Raf, mutant B-Raf, C-Raf) and cell surface receptors (KIT, FLT-3, RET, VEGFR1-3, PDGFR-β). Since they all are involved in angiogenesis and apoptosis, Sorafenib, by blocking proliferation and formation of new vessels, directly affects tumour itself and prevents its further growth. Its targets include serine-threonine Raf kinase, a key component of Raf/MEK/ERK pathway responsible for apoptosis impairment and proliferation of cancer cells.

 

Dosage:

Sorafenib is given on a one hour earlier or 2 hours in the wake of eating without surpassing 2 doses a day. Missing the dosage means avoid the missed measurements and proceed to customary dosing calendar.

 

Safety Measures to be taken after while taking Sorafenib:

Persons with hypertension, midsection torment, heart issues, kidney tumor, and liver infection issues safety oriented routines must be taken before intake of Sorafenib. Pregnancy ought to be maintained a strategic distance from atleast for 2 weeks in the wake of halting Sorafenib. So ladies who are pregnant or plan to wind up pregnant abstain from utilizing the drug as it influences fectus. Individuals with lung disease expending drugs carboplatin, paclitaxel, Abraxane, Onxol, Taxol or gemcitabine and cisplatin are encouraged to not take Sorafenib. Change of measurements is to be finished the accompanying medications amiodarone, ibutilide anticoagulants, for example, warfarin carbamazepine, neomycin, dexamethasone, phenobarbital, dofetilide, phenytoin, procainamide, rifabutin. It diminishes fertility in ladies and men. Keep away from kids encouraging while taking this pharmaceutical

 

Taking Nexavar:

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Sorafenib on an empty stomach, at least 1 hour before or 2 hours after eating.

Do not crush, chew, or break a Sorafenib tablet. Swallow it whole with water.

To be sure this medication is not causing harmful side effects, your blood pressure will need to be checked often. Visit your doctor regularly.

If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are taking Sorafenib. You may need to stop taking the medicine for a short time.

Store at room temperature away from moisture and heat.

 

Precaution

You should not use Sorafenib if you are allergic to it, or if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).

To make sure you can safely take Sorafenib, tell your doctor if you have any of these other conditions:

kidney or liver problems other than cancer;

lung cancer, especially if you are receiving gemcitabine (Gemzar) and cisplatin (Platinol);

a bleeding or blood clotting disorder such as haemophilia;

high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain;

a personal or family history of Long QT syndrome;

a history of stroke or heart attack; or any allergies.

Do not use Sorafenib if you are pregnant. It could harm the unborn baby. Use effective birth control while you are using this medication and for at least 2 weeks after your treatment ends, whether you are a man or a woman. Sorafenib use by either parent may cause birth defects.

It is not known whether Sorafenib passes into breast milk or if it could harm a nursing baby. Do not breast-feed while using this medication.

 

Adverse Effects of Sorafenib:

Sorafenib can bring about symptoms, for example, loose bowels, sickness, loss of craving, weight reduction, exhaustion, sore mouth, dry mouth, skin inflammation, hair diminishing, hypertension, stomach agony and hand–foot skin syndrome. This is not a complete rundown of every symptom. Do agree with your specialist and take after his instructions totally when you are taking Sorafenib.

 

Buy Sorafenib

With the help of Shabbir Medical Hall, you can order Sorafenib tablets for a fraction of the cost. Majority of molecules are synthesised and packaged in Hong Kong, and after being tested (this is a very important step to guarantee high-quality products) are distributed all over the world. Now patients can get chemotherapy and carcinoma medications delivered to their doorsteps within 2-3 weeks. Not a single person needs to die anymore because of the lack of treatment.

 

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