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Imatinib

US Brand Name: Imatib
Generic Name: Imatinib Mesylate,
Other Brand Name: Gleevec, Veenat
Manufacturer: Natco
Packing: 6, 10, 6
Form: Tablet
Strength: 400 mg, 100 mg, 400 mg
Imatinib is a kind of anticancer drug. This drug is used to treat the certain leukaemia cancer and other types of blood cancer. This drug also helps to treat gastrointestinal stromal tumours (GIST), Dermatofibrosarcoma protuberans.

Imatinib belongs to a class of medicines that are known as kinase inhibitors. It works by jamming the activity of a certain naturally occurring stuff that may be required to help cancer cells multiply. This prevents the multiplication and spreading of cancer cells

 

Mode of action

The mesylate erlotinib salt of Imatinib, a tyrosine kinase inhibitor with antineoplastic Gefitinib activity. Imatinib binds to an intracellular pocket located armodafinil within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This androgel agent inhibits TK encoded by the bcr-abl oncogene as well as receptor lyrica TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological modafinil malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST).

 

Dosage

Imatinib is available on the market in tablet forms of 100 mg and 400 mg. The dose varies in children from 260/m2 per day to 340/m2 per day, but should never exceed 600 mg a day. In adults, it varies from 400 mg to 800 mg per day, as per the physician’s prescription.

 

Drug interactions:

Imatinib has a total of 698 drug interactions within which 41 drugs show major interaction. As Imatinib is metabolized by CYP3A4, every other drug which affects the activity of CYP3A4 can also change the concentration of Imatinib in the blood plasma, causing side effects. Some of the 41 drugs known to cause major interaction with Imatinib, are mentioned below:

  1. Antifungal and antibiotics like ketoconazole, itraconazole, and clarithromycin, block CYP3A4 and increase the level of Imatinib in the blood, causing side effects.
  2. Bactericidals like rifampin and rifabutin increase the activity of CYP3A4, decreasing the efficacy and level of Imatinib in the blood stream.
  3. Other substrates of CYP3A4 like metoprolol, paracetamol, warfarin, and immunosuppressanta, are contraindicated to be administered along with Imatinib, as the plasma concentration of these drugs can increase due to inhibition of CYP3A4 by Imatinib, hence causing severe side effects.

 

The following side effects can be seen after long-term or short-term use of Imatinib:

  1. Taste changes, loss of appetite, stomach ache, nausea, vomiting, bloating, diarrhoea, bloody stool, tarry stool, and constipation.
  2. Weakness, dizziness, anxiety, depression, confusion, and trouble sleeping.
  3. Cough, fever, chills, sore throat, night sweat, stuffy nose, runny nose, shortness of breath, chest tightness, chest pain, and irregular heart beat.
  4. Headache, joint pain, muscle pain, and bone pain.
  5. Hair loss, increased tearing, change in amount of urine production, change in colour of urine, unusual and sudden weight gain or weight loss, and swelling of hand, feet, or face.
  6. Vision problem, slurred speech, and problem swallowing.
  7. Skin irritation, skin rashes, blistering or peeling of skin, increased bruising, skin and eye yellowing

 

How to take it?

Either take the medicines as prescribed by the doctor or as prescribed in the leaflet provided with the drug in case of any confusion. The tablet should be taken with meal and a full of water. Imatinib comes as a tablet to take by mouth. Take Imatinib at around the same time every day. Take the tablet with one glass full of water or exactly as directed by your physician. Do not break the tablet.

 

Over dosage

Symptoms

Abdominal pain; anorexia; ascites; decreased appetite; decreased neutrophil count; decreased WBC; diarrhoea; oedema; elevated bilirubin, CPK, liver transaminase levels, and/or serum creatinine; facial swelling; fatigue; GI pain; headache; muscle spasms; myalgia; nausea; pancytopenia; pyrexia; rash erythema; severe muscle cramps; swelling; thrombocytopenia; vomiting; weakness.

 

Where to buy Imatinib

This drug Imatinib is available in our online pharmacies under the brand name Imatinib 100 mg and Imatib 400 mg. At Shabbir Medical Hall online pharmacy, we provide the drug in various pack sizes.

With the help of Shabbir Medical Hall, you can order Imatinib tablets for a fraction of the cost. Majority of molecules are synthesised and packaged in Hong Kong, and after being tested (this is a very important step to guarantee high-quality products) are distributed all over the world. Now patients can get chemotherapy and carcinoma medications delivered to their doorsteps within 2-3 weeks. Not a single person needs to die anymore because of the lack of treatment.

 

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